Seroatlas · Human Serome Atlas

DTL

Denticleless protein homolog

Also known as: CDT2, DCAF2, DTL_HUMAN, L2DTL, RAMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZJ0
Gene: DTL
Ensembl: ENSG00000143476
Chromosome: 1
Canonical length: 730 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

730 residues, UniProt reviewed canonical sequence.

>Q9NZJ0|DTL
     1  MLFNSVLRQP QLGVLRNGWS SQYPLQSLLT GYQCSGNDEH TSYGETGVPV PPFGCTFSSA
    61  PNMEHVLAVA NEEGFVRLYN TESQSFRKKC FKEWMAHWNA VFDLAWVPGE LKLVTAAGDQ
   121  TAKFWDVKAG ELIGTCKGHQ CSLKSVAFSK FEKAVFCTGG RDGNIMVWDT RCNKKDGFYR
   181  QVNQISGAHN TSDKQTPSKP KKKQNSKGLA PSVDFQQSVT VVLFQDENTL VSAGAVDGII
   241  KVWDLRKNYT AYRQEPIASK SFLYPGSSTR KLGYSSLILD STGSTLFANC TDDNIYMFNM
   301  TGLKTSPVAI FNGHQNSTFY VKSSLSPDDQ FLVSGSSDEA AYIWKVSTPW QPPTVLLGHS
   361  QEVTSVCWCP SDFTKIATCS DDNTLKIWRL NRGLEEKPGG DKLSTVGWAS QKKKESRPGL
   421  VTVTSSQSTP AKAPRAKCNP SNSSPSSAAC APSCAGDLPL PSNTPTFSIK TSPAKARSPI
   481  NRRGSVSSVS PKPPSSFKMS IRNWVTRTPS SSPPITPPAS ETKIMSPRKA LIPVSQKSSQ
   541  AEACSESRNR VKRRLDSSCL ESVKQKCVKS CNCVTELDGQ VENLHLDLCC LAGNQEDLSK
   601  DSLGPTKSSK IEGAGTSISE PPSPISPYAS ESCGTLPLPL RPCGEGSEMV GKENSSPENK
   661  NWLLAMAAKR KAENPSPRSP SSQTPNSRRQ SGKKLPSPVT ITPSSMRKIC TYFHRKSQED
   721  FCGPEHSTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 14 nTPM
thymus: 13 nTPM
testis: 13 nTPM
tonsil: 6 nTPM
lymph node: 5.2 nTPM
rectum: 4.5 nTPM

Single-cell type

erythrocyte progenitors: 142 nCPM
megakaryocyte progenitors: 118 nCPM
monocyte progenitors: 102 nCPM
early primary spermatocytes: 78 nCPM
neutrophil progenitors: 78 nCPM
late primary spermatocytes: 60 nCPM

Immune cell

T-reg: 2 nTPM
memory CD8 T-cell: 0.5 nTPM
memory CD4 T-cell: 0.3 nTPM
total PBMC: 0.3 nTPM
gdT-cell: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

pons: 0.3 nTPM
thalamus: 0.3 nTPM
cerebral cortex: 0.2 nTPM
midbrain: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0
gnomAD missense Z: 1.78
DepMap mean gene effect: -2.17
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
WD repeat-containing CDT2 adapter protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DTL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DTL as an antibody target. Whether an autoantibody or antibody against DTL could matter depends on whether native DTL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DTL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DTL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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