Seroatlas · Human Serome Atlas

DCAF6

DDB1- and CUL4-associated factor 6

Also known as: DCAF6_HUMAN, IQWD1, PC326

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q58WW2
Gene
DCAF6
Ensembl
ENSG00000143164
Chromosome
1
Canonical length
860 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

860 residues, UniProt reviewed canonical sequence.

>Q58WW2|DCAF6
     1  MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN
    61  DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTNDKQ IVSCSGDGVI
   121  FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE
   181  DCKDDILINC RRAATSVAIC PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM
   241  VARFIPSHLN NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE
   301  ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS RWFEEASEVA
   361  QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME VDTPAEQFLQ PSTSSTMSAQ
   421  AHSTSSPTES PHSTPLLSSP DSEQRQSVEA SGHHTHHQSD NNNEKLSPKP GTGEPVLSLH
   481  YSTEGTTTST IKLNFTDEWS SIASSSRGIG SHCKSEGQEE SFVPQSSVQP PEGDSETKAP
   541  EESSEDVTKY QEGVSAENPV ENHINITQSD KFTAKPLDSN SGERNDLNLD RSCGVPEESA
   601  SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA HEETSTRDSA LQDTDDSDDD
   661  PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD TLNIRRPLVK MVYKGHRNSR
   721  TMIKEANFWG ANFVMSGSDC GHIFIWDRHT AEHLMLLEAD NHVVNCLQPH PFDPILASSG
   781  IDYDIKIWSP LEESRIFNRK LADEVITRNE LMLEETRNTI TVPASFMLRM LASLNHIRAD
   841  RLEGDRSEGS GQENENEDEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
586 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 586 nTPM
  • tongue: 429 nTPM
  • heart muscle: 119 nTPM
  • liver: 89 nTPM
  • testis: 77 nTPM
  • adrenal gland: 43 nTPM

Single-cell type

  • late spermatids: 1,106 nCPM
  • cardiomyocytes: 600 nCPM
  • myonuclei: 592 nCPM
  • early spermatids: 557 nCPM
  • adrenal cortex cells: 414 nCPM
  • sertoli cells: 404 nCPM

Immune cell

  • non-classical monocyte: 12 nTPM
  • eosinophil: 10 nTPM
  • intermediate monocyte: 7.5 nTPM
  • myeloid DC: 6 nTPM
  • neutrophil: 5.8 nTPM
  • classical monocyte: 5.5 nTPM

Brain region

  • choroid plexus: 55 nTPM
  • cerebral cortex: 54 nTPM
  • basal ganglia: 43 nTPM
  • white matter: 36 nTPM
  • hippocampal formation: 35 nTPM
  • amygdala: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.09
gnomAD missense Z
2.02
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF6 as an antibody target. Whether an autoantibody or antibody against DCAF6 could matter depends on whether native DCAF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCAF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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