Seroatlas · Human Serome Atlas

RBBP5

Retinoblastoma-binding protein 5

Also known as: RBBP5_HUMAN, RBQ3, SWD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15291
Gene
RBBP5
Ensembl
ENSG00000117222
Chromosome
1
Canonical length
538 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q15291|RBBP5
     1  MNLELLESFG QNYPEEADGT LDCISMALTC TFNRWGTLLA VGCNDGRIVI WDFLTRGIAK
    61  IISAHIHPVC SLCWSRDGHK LVSASTDNIV SQWDVLSGDC DQRFRFPSPI LKVQYHPRDQ
   121  NKVLVCPMKS APVMLTLSDS KHVVLPVDDD SDLNVVASFD RRGEYIYTGN AKGKILVLKT
   181  DSQDLVASFR VTTGTSNTTA IKSIEFARKG SCFLINTADR IIRVYDGREI LTCGRDGEPE
   241  PMQKLQDLVN RTPWKKCCFS GDGEYIVAGS ARQHALYIWE KSIGNLVKIL HGTRGELLLD
   301  VAWHPVRPII ASISSGVVSI WAQNQVENWS AFAPDFKELD ENVEYEERES EFDIEDEDKS
   361  EPEQTGADAA EDEEVDVTSV DPIAAFCSSD EELEDSKALL YLPIAPEVED PEENPYGPPP
   421  DAVQTSLMDE GASSEKKRQS SADGSQPPKK KPKTTNIELQ GVPNDEVHPL LGVKGDGKSK
   481  KKQAGRPKGS KGKEKDSPFK PKLYKGDRGL PLEGSAKGKV QAELSQPLTA GGAISELL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBBP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 12 nTPM
  • tonsil: 12 nTPM
  • kidney: 12 nTPM
  • lymph node: 11 nTPM
  • liver: 10 nTPM
  • thyroid gland: 9.2 nTPM

Single-cell type

  • neutrophils: 85 nCPM
  • thymocytes: 57 nCPM
  • neutrophil progenitors: 48 nCPM
  • erythrocyte progenitors: 48 nCPM
  • corticotrophs: 44 nCPM
  • t-cells: 44 nCPM

Immune cell

  • basophil: 22 nTPM
  • neutrophil: 12 nTPM
  • naive CD8 T-cell: 8.7 nTPM
  • MAIT T-cell: 8.5 nTPM
  • non-classical monocyte: 8.3 nTPM
  • NK-cell: 8.2 nTPM

Brain region

  • cerebellum: 19 nTPM
  • white matter: 19 nTPM
  • cerebral cortex: 18 nTPM
  • hippocampal formation: 18 nTPM
  • hypothalamus: 17 nTPM
  • basal ganglia: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RBBP5.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 41 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • RBBP5-related syndromic neurodevelopmental condition

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
3.59
DepMap mean gene effect
-0.95
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBBP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBBP5 as an antibody target. Whether an autoantibody or antibody against RBBP5 could matter depends on whether native RBBP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBBP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBBP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBBP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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