Seroatlas · Human Serome Atlas

WDTC1

WD and tetratricopeptide repeats protein 1

Also known as: ADP, DCAF9, KIAA1037, WDTC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5D0
Gene: WDTC1
Ensembl: ENSG00000142784
Chromosome: 1
Canonical length: 677 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>Q8N5D0|WDTC1
     1  MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD
    61  LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD
   121  LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY
   181  CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK
   241  PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK
   301  QRPYTFLLPR KCHSSGEVQN GKMSTNGVSN GVSNGLHLHS NGFRLPESRG HVSPQVELPP
   361  YLERVKQQAN EAFACQQWTQ AIQLYSKAVQ RAPHNAMLYG NRAAAYMKRK WDGDHYDALR
   421  DCLKAISLNP CHLKAHFRLA RCLFELKYVA EALECLDDFK GKFPEQAHSS ACDALGRDIT
   481  AALFSKNDGE EKKGPGGGAP VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI
   541  KEANFFGSNA QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI
   601  DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNADPL EVMLLNMGYR ITGLSSGGAG
   661  ASDDEDSSEG QVQCRPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDTC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 60 nTPM
tongue: 51 nTPM
parathyroid gland: 45 nTPM
testis: 36 nTPM
heart muscle: 34 nTPM
retina: 31 nTPM

Single-cell type

rod photoreceptor cells: 241 nCPM
cone photoreceptor cells: 176 nCPM
neutrophils: 167 nCPM
late spermatids: 111 nCPM
respiratory ciliated cells: 86 nCPM
neutrophil progenitors: 84 nCPM

Immune cell

eosinophil: 2.8 nTPM
neutrophil: 2.1 nTPM
gdT-cell: 1.4 nTPM
myeloid DC: 0.7 nTPM
memory B-cell: 0.6 nTPM
memory CD8 T-cell: 0.6 nTPM

Brain region

amygdala: 56 nTPM
cerebral cortex: 56 nTPM
medulla oblongata: 56 nTPM
pons: 55 nTPM
thalamus: 53 nTPM
basal ganglia: 50 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDTC1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 87 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

WDTC1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 3.81
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDTC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDTC1 as an antibody target. Whether an autoantibody or antibody against WDTC1 could matter depends on whether native WDTC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDTC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDTC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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