Seroatlas · Human Serome Atlas

CDT1

DNA replication factor Cdt1

Also known as: CDT1_HUMAN, DUP, RIS2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H211
Gene
CDT1
Ensembl
ENSG00000167513
Chromosome
16
Canonical length
546 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>Q9H211|CDT1
     1  MEQRRVTDFF ARRRPGPPRI APPKLACRTP SPARPALRAP ASATSGSRKR ARPPAAPGRD
    61  QARPPARRRL RLSVDEVSSP STPEAPDIPA CPSPGQKIKK STPAAGQPPH LTSAQDQDTI
   121  SELASCLQRA RELGARVRAL KASAQDAGES CTPEAEGRPE EPCGEKAPAY QRFHALAQPG
   181  LPGLVLPYKY QVLAEMFRSM DTIVGMLHNR SETPTFAKVQ RGVQDMMRRR FEECNVGQIK
   241  TVYPASYRFR QERSVPTFKD GTRRSDYQLT IEPLLEQEAD GAAPQLTASR LLQRRQIFSQ
   301  KLVEHVKEHH KAFLASLSPA MVVPEDQLTR WHPRFNVDEV PDIEPAALPQ PPATEKLTTA
   361  QEVLARARNL ISPRMEKALS QLALRSAAPS SPGSPRPALP ATPPATPPAA SPSALKGVSQ
   421  DLLERIRAKE AQKQLAQMTR CPEQEQRLQR LERLPELARV LRSVFVSERK PALSMEVACA
   481  RMVGSCCTIM SPGEMEKHLL LLSELLPDWL SLHRIRTDTY VKLDKAADLA HITARLAHQT
   541  RAEEGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 36 nTPM
  • thymus: 8.1 nTPM
  • esophagus: 7.7 nTPM
  • lymph node: 4.4 nTPM
  • skin: 4.2 nTPM
  • testis: 4 nTPM

Single-cell type

  • extravillous trophoblasts: 102 nCPM
  • erythrocyte progenitors: 84 nCPM
  • migrating cytotrophoblasts: 83 nCPM
  • differentiating spermatogonia: 63 nCPM
  • enteric transient amplifying cells: 59 nCPM
  • cytotrophoblasts: 58 nCPM

Immune cell

  • eosinophil: 0.9 nTPM
  • neutrophil: 0.7 nTPM
  • T-reg: 0.7 nTPM
  • NK-cell: 0.4 nTPM
  • gdT-cell: 0.3 nTPM
  • myeloid DC: 0.3 nTPM

Brain region

  • cerebellum: 8.3 nTPM
  • hypothalamus: 8 nTPM
  • pons: 7.6 nTPM
  • medulla oblongata: 6.6 nTPM
  • cerebral cortex: 6.2 nTPM
  • basal ganglia: 5.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDT1.

Disease | AllUniProt

Conditions CDT1 is implicated in, by any mechanism.

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 548 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
-1.9
DepMap mean gene effect
-1.77
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Winged helix DNA-binding domain superfamily
  • CDT1 Geminin-binding domain-like
  • DNA replication factor Cdt1, C-terminal
  • DNA replication factor Cdt1, C-terminal WH domain superfamily
  • DNA replication factor Cdt1
  • DNA replication factor CDT1 like
  • DNA replication factor Cdt1 C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDT1 as an antibody target. Whether an autoantibody or antibody against CDT1 could matter depends on whether native CDT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...