Seroatlas · Human Serome Atlas

DET1

DET1 homolog

Also known as: DET1_HUMAN, FLJ10103

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L5Y6
Gene: DET1
Ensembl: ENSG00000140543
Chromosome: 15
Canonical length: 550 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules,Cytokinetic bridge

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q7L5Y6|DET1
     1  MDHHVSTIKP RRIQNQNVIH RLERRRISSG KAGTHWHQVR VFHQNVFPNF TVVNVEKPPC
    61  FLRKFSPDGR YFIAFSSDQT SLEIYEYQGC QAAEDLLQGY EGEILSNGND QRSVNIRGRL
   121  FERFFVLLHI TNVAANGEHL NRECSLFTDD CRCVIVGSAA YLPDEPHPPF FEVYRNSESV
   181  TPNPRSPLED YSLHIIDLHT GRLCDTRTFK CDKVVLSHNQ GLYLYKNILA ILSVQQQTIH
   241  VFQVTPEGTF IDVRTIGRFC YEDDLLTVSA VFPEVQRDSQ TGMANPFRDP FINSLKHRLL
   301  VYLWRRAEQD GSAMAKRRFF QYFDQLRQLR MWKMQLLDEN HLFIKYTSED VVTLRVTDPS
   361  QASFFVVYNM VTTEVIAVFE NTSDELLELF ENFCDLFRNA TLHSEVQFPC SASSNNFARQ
   421  IQRRFKDTII NAKYGGHTEA VRRLLGQLPI SAQSYSGSPY LDLSLFSYDD KWVSVMERPK
   481  TCGDHPIRFY ARDSGLLKFE IQAGLLGRPI NHTVRRLVAF TFHPFEPFAI SVQRTNAEYV
   541  VNFHMRHCCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DET1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

tongue: 11 nTPM
skeletal muscle: 9.1 nTPM
ovary: 8.1 nTPM
endometrium: 6.3 nTPM
cervix: 5.3 nTPM
fallopian tube: 5.3 nTPM

Single-cell type

podocytes: 33 nCPM
loop of henle epithelial cells: 31 nCPM
renal collecting duct intercalated cells: 29 nCPM
distal convoluted tubule cells: 29 nCPM
renal collecting duct principal cells: 27 nCPM
papillary tip epithelial cells: 24 nCPM

Immune cell

myeloid DC: 3.7 nTPM
intermediate monocyte: 3.5 nTPM
naive CD4 T-cell: 2.6 nTPM
T-reg: 2.4 nTPM
classical monocyte: 2.3 nTPM
gdT-cell: 2.3 nTPM

Brain region

choroid plexus: 5.2 nTPM
white matter: 5.1 nTPM
basal ganglia: 4.3 nTPM
cerebral cortex: 4.3 nTPM
pons: 4.3 nTPM
cerebellum: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.68
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

De-etiolated protein 1, Det1
De-etiolated protein 1 Det1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DET1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DET1 as an antibody target. Whether an autoantibody or antibody against DET1 could matter depends on whether native DET1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DET1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DET1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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