Seroatlas · Human Serome Atlas

PCGF6

Polycomb group RING finger protein 6

Also known as: MBLR, PCGF6_HUMAN, RNF134

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYE7
Gene
PCGF6
Ensembl
ENSG00000156374
Chromosome
10
Canonical length
350 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9BYE7|PCGF6
     1  MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE TGAPGCSGSR
    61  PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED MSHFSLRLEG GRQDSEDEEE
   121  RLINLSELTP YILCSICKGY LIDATTITEC LHTFCKSCIV RHFYYSNRCP KCNIVVHQTQ
   181  PLYNIRLDRQ LQDIVYKLVI NLEEREKKQM HDFYKERGLE VPKPAVPQPV PSSKGRSKKV
   241  LESVFRIPPE LDMSLLLEFI GANEGTGHFK PLEKKFVRVS GEATIGHVEK FLRRKMGLDP
   301  ACQVDIICGD HLLEQYQTLR EIRRAIGDAA MQDGLLVLHY GLVVSPLKIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCGF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • liver: 11 nTPM
  • skeletal muscle: 10 nTPM
  • testis: 8.3 nTPM
  • colon: 7.2 nTPM
  • smooth muscle: 7 nTPM
  • blood vessel: 6.9 nTPM

Single-cell type

  • early primary spermatocytes: 114 nCPM
  • adipocytes: 41 nCPM
  • erythrocyte progenitors: 35 nCPM
  • brain inhibitory neurons: 34 nCPM
  • differentiating spermatogonia: 34 nCPM
  • brain excitatory neurons: 34 nCPM

Immune cell

  • basophil: 5.4 nTPM
  • T-reg: 4.1 nTPM
  • naive CD4 T-cell: 3.7 nTPM
  • NK-cell: 3.6 nTPM
  • MAIT T-cell: 3.4 nTPM
  • naive CD8 T-cell: 3.2 nTPM

Brain region

  • white matter: 4 nTPM
  • pons: 3.5 nTPM
  • spinal cord: 3.5 nTPM
  • cerebellum: 3.2 nTPM
  • medulla oblongata: 3.1 nTPM
  • basal ganglia: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCGF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCGF6 as an antibody target. Whether an autoantibody or antibody against PCGF6 could matter depends on whether native PCGF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCGF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCGF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCGF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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