Seroatlas · Human Serome Atlas

GPATCH2L

G patch domain-containing protein 2-like

Also known as: C14orf118, FLJ10033, FLJ20689, GPT2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWQ4
Gene: GPATCH2L
Ensembl: ENSG00000089916
Chromosome: 14
Canonical length: 482 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q9NWQ4|GPATCH2L
     1  MDELVHDLAS ALEQTSEQNK LGELWEEMAL SPRQQRRQLR KRRGRKRRSD FTHLAEHTCC
    61  YSEASESSLD EATKDCREVA PVTNFSDSDD TMVAKRHPAL NAIVKSKQHS WHESDSFTEN
   121  APCRPLRRRR KVKRVTSEVA ASLQQKLKVS DWSYERGCRF KSAKKQRLSR WKENTPWTSS
   181  GHGLCESAEN RTFLSKTGRK ERMECETDEQ KQGSDENMSE CETSSVCSSS DTGLFTNDEG
   241  RQGDDEQSDW FYEGECVPGF TVPNLLPKWA PDHCSEVERM DSGLDKFSDS TFLLPSRPAQ
   301  RGYHTRLNRL PGAAARCLRK GRRRLVGKET SINTLGTERI SHIISDPRQK EKNKALASDF
   361  PHISACAHEF NPLSPLYSLD VLADASHRRC SPAHCSARQA NVHWGPPCSR DIKRKRKPVA
   421  TASLSSPSAV HMDAVEPTTP ASQAPKSPSS EWLVRTSAAE KATDATTATF FKMPQEKSPG
   481  YS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPATCH2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 35 nTPM
retina: 14 nTPM
tongue: 13 nTPM
testis: 13 nTPM
heart muscle: 12 nTPM
appendix: 11 nTPM

Single-cell type

early spermatids: 221 nCPM
myonuclei: 212 nCPM
late spermatids: 203 nCPM
neutrophils: 189 nCPM
microglia: 186 nCPM
distal convoluted tubule cells: 168 nCPM

Immune cell

eosinophil: 8 nTPM
classical monocyte: 7.3 nTPM
myeloid DC: 7.3 nTPM
intermediate monocyte: 6.6 nTPM
memory B-cell: 6.4 nTPM
neutrophil: 5.7 nTPM

Brain region

white matter: 44 nTPM
choroid plexus: 41 nTPM
cerebellum: 40 nTPM
spinal cord: 39 nTPM
hypothalamus: 39 nTPM
medulla oblongata: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Splicing-associated domain-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPATCH2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPATCH2L as an antibody target. Whether an autoantibody or antibody against GPATCH2L could matter depends on whether native GPATCH2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPATCH2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPATCH2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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