Seroatlas · Human Serome Atlas

CSNK2A2IP

Casein kinase II subunit alpha'-interacting protein

Also known as: CS2IP_HUMAN, CSNKA2IP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GTH6
Gene: CSNK2A2IP
Ensembl: ENSG00000283434
Chromosome: 3
Canonical length: 734 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in male germ cell nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

734 residues, UniProt reviewed canonical sequence.

>A0A1B0GTH6|CSNK2A2IP
     1  MVPLAYYGQH FVPLDYFYQL SSANTLTHQH TGEKLNQFNN QPMAKVQSHS NHFAVPPLGS
    61  NKKVQRCSVL PSPKSQDKIS QSFCDRFLNS PLFHAKHQNT PSIGLHWRSS LWPAQRALNS
   121  HLLHSKAQTT SSSDLNMTSS LELNQAALSL QLPFCKPQTT SSSLDVCWRS LSLKSHQRVS
   181  SSSLFRLQNQ EIPSINIIWT SSSLGPKRKA LSSTLLQSKP QKTSSLDYLW TSSLQRNQRS
   241  LSSPSLNTKL QTSDLFWTSP SFKPNQIALT SPLLDSRLQK TPILNSNPTI GGLPVSHSKA
   301  RQSASSYFVH PSENLPLFQL NSQSMFMLDC NFQTTNSPVC HSKFQNTTSP NGKHRVTHLP
   361  SPHPKTNISG QLLSSSKHCT RNTAASTLGF RLQSKSSFQF SPKTESNKEI PWTLKYSQPC
   421  IVKGGTVPDD VVNKIVNSIS NTRIQRDLCR QILFRRMRGR PNPHPGPRLS SNYVVCLACA
   481  SCLKSPCNHL RGKKNPHCAT LSVIPTPEAN SEGKIEVKLV LILSLPETFS SCLPFPMKEN
   541  QPNEVPEDNL EGVEKIQQFF PTSERDIQGL NMKQIWWAVA PENKVIGQQP QAIDWLFYVK
   601  KNNSQPQSLL PSTSSSTSSS STTSSSSSVA SASSDSSSSS SSSSSFSISS SSSPSKEFMT
   661  LTLSRPVFRK VLSYHRLPAG VSWLEFIYSK DYQLHPRKPN RSQSSSLKTK PVRNNNTVKW
   721  RKGANTLFKF FRTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK2A2IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 415 nCPM
early spermatids: 163 nCPM
late primary spermatocytes: 100 nCPM
brain excitatory neurons: 6.8 nCPM
brain inhibitory neurons: 5.5 nCPM
epicardial cells: 4.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
white matter: 0.3 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
thalamus: 0.1 nTPM

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Casein kinase II subunit alpha'-interacting protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK2A2IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CSNK2A2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK2A2IP as an antibody target. Whether an autoantibody or antibody against CSNK2A2IP could matter depends on whether native CSNK2A2IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK2A2IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK2A2IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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