Seroatlas · Human Serome Atlas

GTF3C5

General transcription factor 3C polypeptide 5

Also known as: TF3C5_HUMAN, TFiiiC2-63, TFIIIC63, TFIIICepsilon

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5Q8
Gene
GTF3C5
Ensembl
ENSG00000148308
Chromosome
9
Canonical length
519 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within skeletal muscle cell differentiation. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q9Y5Q8|GTF3C5
     1  MAAEAADLGL GAAVPVELRR ERRMVCVEYP GVVRDVAKML PTLGGEEGVS RIYADPTKRL
    61  ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRQKGVLG TEAHSEVTFD MEILGIISTI
   121  YKFQGMSDFQ YLAVHTEAGG KHTSMYDKVL MLRPEKEAFF HQELPLYIPP PIFSRLDAPV
   181  DYFYRPETQH REGYNNPPIS GENLIGLSRA RRPHNAIFVN FEDEEVPKQP LEAAAQTWRR
   241  VCTNPVDRKV EEELRKLFDI RPIWSRNAVK ANISVHPDKL KVLLPFIAYY MITGPWRSLW
   301  IRFGYDPRKN PDAKIYQVLD FRIRCGMKHG YAPSDLPVKA KRSTYNYSLP ITVKKTSSQL
   361  VTMHDLKQGL GPSGTSGARK PASSKYKLKD SVYIFREGAL PPYRQMFYQL CDLNVEELQK
   421  IIHRNDGAEN SCTERDGWCL PKTSDELRDT MSLMIRQTIR SKRPALFSSS AKADGGKEQL
   481  TYESGEDEED EEEEEEEEED FKPSDGSENE METEILDYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF3C5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 56 nTPM
  • skeletal muscle: 51 nTPM
  • ovary: 48 nTPM
  • thymus: 42 nTPM
  • esophagus: 41 nTPM
  • skin: 41 nTPM

Single-cell type

  • breast lactating cells: 105 nCPM
  • epididymal principal cells: 86 nCPM
  • esophageal basal cells: 64 nCPM
  • esophageal suprabasal cells: 53 nCPM
  • granulosa cells: 51 nCPM
  • migrating cytotrophoblasts: 51 nCPM

Immune cell

  • basophil: 54 nTPM
  • MAIT T-cell: 23 nTPM
  • eosinophil: 23 nTPM
  • NK-cell: 21 nTPM
  • memory CD8 T-cell: 21 nTPM
  • T-reg: 19 nTPM

Brain region

  • white matter: 50 nTPM
  • cerebellum: 49 nTPM
  • cerebral cortex: 41 nTPM
  • basal ganglia: 38 nTPM
  • medulla oblongata: 36 nTPM
  • midbrain: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.77
DepMap mean gene effect
-0.64
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transcription factor IIIC subunit 5, HTH domain
  • Transcription factor IIIC subunit Tfc1/Sfc1
  • Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain
  • TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily
  • RNA polymerase III transcription factor (TF)IIIC subunit HTH domain
  • Tau95 Triple barrel domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GTF3C5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTF3C5 as an antibody target. Whether an autoantibody or antibody against GTF3C5 could matter depends on whether native GTF3C5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTF3C5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTF3C5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GTF3C5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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