PCGF3
Polycomb group RING finger protein 3
Also known as: DONG1, FLJ36550, MGC40413, PCGF3_HUMAN, RNF3, RNF3A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q3KNV8
- Gene
- PCGF3
- Ensembl
- ENSG00000185619
- Chromosome
- 4
- Canonical length
- 242 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
242 residues, UniProt reviewed canonical sequence.
>Q3KNV8|PCGF3
1 MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH
61 QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD
121 SHRNGETKAD DSSNKEAAEE KPEEDNDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA
181 TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD
241 LLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PCGF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 55 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 55 nTPM
- skin: 52 nTPM
- ovary: 49 nTPM
- spleen: 49 nTPM
- adrenal gland: 44 nTPM
- cervix: 39 nTPM
Single-cell type
- epicardial cells: 189 nCPM
- cardiomyocytes: 148 nCPM
- oocytes: 134 nCPM
- esophageal apical cells: 109 nCPM
- neutrophils: 103 nCPM
- adrenal cortex cells: 102 nCPM
Immune cell
- classical monocyte: 7.3 nTPM
- intermediate monocyte: 5.2 nTPM
- NK-cell: 5.2 nTPM
- naive B-cell: 5.1 nTPM
- plasmacytoid DC: 4.9 nTPM
- neutrophil: 4.7 nTPM
Brain region
- cerebellum: 65 nTPM
- white matter: 49 nTPM
- cerebral cortex: 42 nTPM
- hippocampal formation: 39 nTPM
- medulla oblongata: 39 nTPM
- basal ganglia: 38 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.34
- gnomAD pLI
- 0.95
- gnomAD missense Z
- 2.1
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PCGF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PCGF3 as an antibody target. Whether an autoantibody or antibody against PCGF3 could matter depends on whether native PCGF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PCGF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PCGF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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