Seroatlas · Human Serome Atlas

GRAMD1B

Protein Aster-B

Also known as: ASTRB_HUMAN, KIAA1201, LINC01059

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KR37
Gene: GRAMD1B
Ensembl: ENSG00000023171
Chromosome: 11
Canonical length: 738 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum,Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

738 residues, UniProt reviewed canonical sequence.

>Q3KR37|GRAMD1B
     1  MKGFKLSCTA SNSNRSTPAC SPILRKRSRS PTPQNQDGDT MVEKGSDHSS DKSPSTPEQG
    61  VQRSCSSQSG RSGGKNSKKS QSWYNVLSPT YKQRNEDFRK LFKQLPDTER LIVDYSCALQ
   121  RDILLQGRLY LSENWICFYS NIFRWETLLT VRLKDICSMT KEKTARLIPN AIQVCTDSEK
   181  HFFTSFGARD RTYMMMFRLW QNALLEKPLC PKELWHFVHQ CYGNELGLTS DDEDYVPPDD
   241  DFNTMGYCEE IPVEENEVND SSSKSSIETK PDASPQLPKK SITNSTLTST GSSEAPVSFD
   301  GLPLEEEALE GDGSLEKELA IDNIMGEKIE MIAPVNSPSL DFNDNEDIPT ELSDSSDTHD
   361  EGEVQAFYED LSGRQYVNEV FNFSVDKLYD LLFTNSPFQR DFMEQRRFSD IIFHPWKKEE
   421  NGNQSRVILY TITLTNPLAP KTATVRETQT MYKASQESEC YVIDAEVLTH DVPYHDYFYT
   481  INRYTLTRVA RNKSRLRVST ELRYRKQPWG LVKTFIEKNF WSGLEDYFRH LESELAKTES
   541  TYLAEMHRQS PKEKASKTTT VRRRKRPHAH LRVPHLEEVM SPVTTPTDED VGHRIKHVAG
   601  STQTRHIPED TPNGFHLQSV SKLLLVISCV ICFSLVLLVI LNMMLFYKLW MLEYTTQTLT
   661  AWQGLRLQER LPQSQTEWAQ LLESQQKYHD TELQKWREII KSSVMLLDQM KDSLINLQNG
   721  IRSRDYTSES EEKRNRYH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRAMD1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 204 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 204 nTPM
cerebellum: 112 nTPM
retina: 89 nTPM
cerebral cortex: 37 nTPM
choroid plexus: 35 nTPM
duodenum: 29 nTPM

Single-cell type

cone photoreceptor cells: 1,246 nCPM
adrenal cortex cells: 1,196 nCPM
proximal tubule cells: 976 nCPM
choroid plexus epithelial cells: 913 nCPM
rod photoreceptor cells: 765 nCPM
distal convoluted tubule cells: 605 nCPM

Immune cell

plasmacytoid DC: 6.8 nTPM
myeloid DC: 1.6 nTPM
NK-cell: 1.6 nTPM
memory CD4 T-cell: 1.5 nTPM
memory CD8 T-cell: 1.2 nTPM
classical monocyte: 1.1 nTPM

Brain region

choroid plexus: 204 nTPM
cerebellum: 201 nTPM
cerebral cortex: 145 nTPM
hippocampal formation: 143 nTPM
thalamus: 104 nTPM
pons: 92 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GRAMD1B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 111 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 3.23
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRAMD1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRAMD1B as an antibody target. Whether an autoantibody or antibody against GRAMD1B could matter depends on whether native GRAMD1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRAMD1B is annotated at the cell surface, where native GRAMD1B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GRAMD1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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