Seroatlas · Human Serome Atlas

GPATCH2

G patch domain-containing protein 2

Also known as: CT110, FLJ10252, GPATC2, GPTC2_HUMAN, Pfa1, PPP1R30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NW75
Gene: GPATCH2
Ensembl: ENSG00000092978
Chromosome: 1
Canonical length: 528 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>Q9NW75|GPATCH2
     1  MFGAAGRQPI GAPAAGNSWH FSRTMEELVH DLVSALEESS EQARGGFAET GDHSRSISCP
    61  LKRQARKRRG RKRRSYNVHH PWETGHCLSE GSDSSLEEPS KDYRENHNNN KKDHSDSDDQ
   121  MLVAKRRPSS NLNNNVRGKR PLWHESDFAV DNVGNRTLRR RRKVKRMAVD LPQDISNKRT
   181  MTQPPEGCRD QDMDSDRAYQ YQEFTKNKVK KRKLKIIRQG PKIQDEGVVL ESEETNQTNK
   241  DKMECEEQKV SDELMSESDS SSLSSTDAGL FTNDEGRQGD DEQSDWFYEK ESGGACGITG
   301  VVPWWEKEDP TELDKNVPDP VFESILTGSF PLMSHPSRRG FQARLSRLHG MSSKNIKKSG
   361  GTPTSMVPIP GPVGNKRMVH FSPDSHHHDH WFSPGARTEH DQHQLLRDNR AERGHKKNCS
   421  VRTASRQTSM HLGSLCTGDI KRRRKAAPLP GPTTAGFVGE NAQPILENNI GNRMLQNMGW
   481  TPGSGLGRDG KGISEPIQAM QRPKGLGLGF PLPKSTSATT TPNAGKSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPATCH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 6.7 nTPM

Expression across tissuesHPA

Tissue

breast: 6.7 nTPM
parathyroid gland: 6.5 nTPM
prostate: 6.5 nTPM
skeletal muscle: 6.2 nTPM
thyroid gland: 6.2 nTPM
endometrium: 6.1 nTPM

Single-cell type

choroid plexus epithelial cells: 319 nCPM
cardiomyocytes: 255 nCPM
gonadotrophs: 236 nCPM
pituicytes/fscs: 232 nCPM
prostatic glandular cells: 213 nCPM
lactotrophs: 185 nCPM

Immune cell

plasmacytoid DC: 5 nTPM
basophil: 4.1 nTPM
myeloid DC: 3.4 nTPM
classical monocyte: 3.1 nTPM
memory CD4 T-cell: 3 nTPM
non-classical monocyte: 2.9 nTPM

Brain region

choroid plexus: 18 nTPM
hypothalamus: 15 nTPM
cerebral cortex: 14 nTPM
hippocampal formation: 13 nTPM
basal ganglia: 13 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

nucleic acid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPATCH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPATCH2 as an antibody target. Whether an autoantibody or antibody against GPATCH2 could matter depends on whether native GPATCH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPATCH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPATCH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...