Seroatlas · Human Serome Atlas

PES1

Pescadillo homolog

Also known as: NOP7, PES, PESC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00541
Gene: PES1
Ensembl: ENSG00000100029
Chromosome: 22
Canonical length: 588 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>O00541|PES1
     1  MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA
    61  ARTFYLIKDI RFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPNYKLDHII
   121  KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFMH YIIAARALRK
   181  VFLSIKGIYY QAEVLGQPIV WITPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ
   241  LLNLHYPPKL EGQAQAEAKA GEGTYALDSE SCMEKLAALS ASLARVVVPA TEEEAEVDEF
   301  PTDGEMSAQE EDRRKELEAQ EKHKKLFEGL KFFLNREVPR EALAFIIRSF GGEVSWDKSL
   361  CIGATYDVTD SRITHQIVDR PGQQTSVIGR CYVQPQWVFD SVNARLLLPV AEYFSGVQLP
   421  PHLSPFVTEK EGDYVPPEKL KLLALQRGED PGNLNESEEE EEEDDNNEGD GDEEGENEEE
   481  EEDAEAGSEK EEEARLAALE EQRMEGKKPR VMAGTLKLED KQRLAQEEES EAKRLAIMMM
   541  KKREKYLYQK IMFGKRRKIR EANKLAEKRK AHDEAVRSEK KAKKARPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PES1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

pancreas: 56 nTPM
choroid plexus: 49 nTPM
liver: 47 nTPM
skeletal muscle: 47 nTPM
skin: 44 nTPM
esophagus: 43 nTPM

Single-cell type

undifferentiated spermatogonia: 71 nCPM
esophageal basal cells: 66 nCPM
oocytes: 60 nCPM
early spermatids: 53 nCPM
epididymal principal cells: 52 nCPM
differentiating spermatogonia: 52 nCPM

Immune cell

intermediate monocyte: 30 nTPM
total PBMC: 29 nTPM
myeloid DC: 27 nTPM
classical monocyte: 25 nTPM
MAIT T-cell: 23 nTPM
plasmacytoid DC: 23 nTPM

Brain region

white matter: 33 nTPM
basal ganglia: 31 nTPM
pons: 29 nTPM
midbrain: 29 nTPM
thalamus: 29 nTPM
medulla oblongata: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.72
gnomAD missense Z: 1.31
DepMap mean gene effect: -1.07
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

BRCT domain
BRCT domain superfamily
BRCT domain
Pescadillo
Pescadillo N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PES1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PES1 as an antibody target. Whether an autoantibody or antibody against PES1 could matter depends on whether native PES1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PES1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PES1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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