Seroatlas · Human Serome Atlas

NKAPD1

Uncharacterized protein NKAPD1

Also known as: C11orf57, FLJ10726, NKAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUT1
Gene: NKAPD1
Ensembl: ENSG00000150776
Chromosome: 11
Canonical length: 292 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q6ZUT1|NKAPD1
     1  MSRIPLGKVL LRNVIRHTDA HNKIQEESDM WKIRELEKQM EDAYRGTKRK MLPSSSSRMR
    61  SDGFDEESQR YYWRPKNEIS GTLEDDFLKA KSWNKKFYDY EANMPDRWGH SGYKELYPEE
   121  FETDSDQQDI TNGKKTSPQV KSSTHESRKH KKSKKSHKKK QKKRSHKKQK KSKKEATDIT
   181  ADSSSEFSEE TGASGTRKGK QPHKRKKKSR KKSLKKPALF LEAESNTSHS DDSASSSSEE
   241  SEERDTKKTK RKKREKKAHT SVANNEIQER TNKRTNWKVA TDERSAESSE DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKAPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

retina: 31 nTPM
cerebellum: 22 nTPM
ovary: 19 nTPM
skeletal muscle: 17 nTPM
thymus: 16 nTPM
breast: 16 nTPM

Single-cell type

esophageal apical cells: 72 nCPM
rod photoreceptor cells: 51 nCPM
late primary spermatocytes: 47 nCPM
megakaryocytes: 37 nCPM
erythrocyte progenitors: 37 nCPM
parietal cells: 34 nCPM

Immune cell

plasmacytoid DC: 21 nTPM
NK-cell: 14 nTPM
naive CD4 T-cell: 11 nTPM
memory CD4 T-cell: 10 nTPM
MAIT T-cell: 10 nTPM
gdT-cell: 9.9 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 18 nTPM
cerebral cortex: 17 nTPM
pons: 17 nTPM
hypothalamus: 17 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.31
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Protein domainsUniProt · Pfam · InterPro

NF-kappa-B-activating protein
Nkap domain containing 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKAPD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKAPD1 as an antibody target. Whether an autoantibody or antibody against NKAPD1 could matter depends on whether native NKAPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKAPD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKAPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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