Seroatlas · Human Serome Atlas

GRAMD1A

Protein Aster-A

Also known as: ASTRA_HUMAN, FLJ90346, KIAA1533

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CP6
Gene
GRAMD1A
Ensembl
ENSG00000089351
Chromosome
19
Canonical length
724 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Located in several cellular components, including cytosol; endoplasmic reticulum membrane; and organelle membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>Q96CP6|GRAMD1A
     1  MFDTTPHSGR STPSSSPSLR KRLQLLPPSR PPPEPEPGTM VEKGSDSSSE KGGVPGTPST
    61  QSLGSRNFIR NSKKMQSWYS MLSPTYKQRN EDFRKLFSKL PEAERLIVDY SCALQREILL
   121  QGRLYLSENW ICFYSNIFRW ETTISIQLKE VTCLKKEKTA KLIPNAIQIC TESEKHFFTS
   181  FGARDRCFLL IFRLWQNALL EKTLSPRELW HLVHQCYGSE LGLTSEDEDY VSPLQLNGLG
   241  TPKEVGDVIA LSDITSSGAA DRSQEPSPVG SRRGHVTPNL SRASSDADHG AEEDKEEQVD
   301  SQPDASSSQT VTPVAEPPST EPTQPDGPTT LGPLDLLPSE ELLTDTSNSS SSTGEEADLA
   361  ALLPDLSGRL LINSVFHVGA ERLQQMLFSD SPFLQGFLQQ CKFTDVTLSP WSGDSKCHQR
   421  RVLTYTIPIS NPLGPKSASV VETQTLFRRG PQAGGCVVDS EVLTQGIPYQ DYFYTAHRYC
   481  ILGLARNKAR LRVSSEIRYR KQPWSLVKSL IEKNSWSGIE DYFHHLEREL AKAEKLSLEE
   541  GGKDARGLLS GLRRRKRPLS WRAHGDGPQH PDPDPCARAG IHTSGSLSSR FSEPSVDQGP
   601  GAGIPSALVL ISIVICVSLI ILIALNVLLF YRLWSLERTA HTFESWHSLA LAKGKFPQTA
   661  TEWAEILALQ KQFHSVEVHK WRQILRASVE LLDEMKFSLE KLHQGITVSD PPFDTQPRPD
   721  DSFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRAMD1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
87 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 87 nTPM
  • lung: 63 nTPM
  • salivary gland: 52 nTPM
  • skeletal muscle: 51 nTPM
  • spleen: 46 nTPM
  • ovary: 43 nTPM

Single-cell type

  • neutrophils: 680 nCPM
  • pancreatic acinar cells: 167 nCPM
  • monocytes: 122 nCPM
  • alveolar cells type 1: 116 nCPM
  • hofbauer cells: 112 nCPM
  • vascular endothelial cells: 98 nCPM

Immune cell

  • basophil: 23 nTPM
  • non-classical monocyte: 20 nTPM
  • neutrophil: 13 nTPM
  • intermediate monocyte: 9.6 nTPM
  • MAIT T-cell: 7.3 nTPM
  • classical monocyte: 5.7 nTPM

Brain region

  • medulla oblongata: 51 nTPM
  • cerebral cortex: 51 nTPM
  • pons: 51 nTPM
  • thalamus: 50 nTPM
  • midbrain: 49 nTPM
  • hypothalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0
gnomAD missense Z
1.29
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRAMD1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRAMD1A as an antibody target. Whether an autoantibody or antibody against GRAMD1A could matter depends on whether native GRAMD1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRAMD1A is annotated at the cell surface, where native GRAMD1A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GRAMD1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRAMD1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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