Seroatlas · Human Serome Atlas

WDR77

Methylosome protein WDR77

Also known as: MEP50, MEP50_HUMAN, p44

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQA1
Gene
WDR77
Ensembl
ENSG00000116455
Chromosome
1
Canonical length
342 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q9BQA1|WDR77
     1  MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL
    61  FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC
   121  KYEHDDIVST VSVLSSGTQA VSGSKDICIK VWDLAQQVVL SSYRAHAAQV TCVAASPHKD
   181  SVFLSCSEDN RILLWDTRCP KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV
   241  DTKSTSCVLS SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV
   301  RDATWSPLNH SLLTTVGWDH QVVHHVVPTE PLPAPGPASV TE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR77 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 99 nTPM
  • skeletal muscle: 43 nTPM
  • tonsil: 34 nTPM
  • tongue: 31 nTPM
  • heart muscle: 30 nTPM
  • esophagus: 28 nTPM

Single-cell type

  • tuft cells: 23 nCPM
  • fallopian secretory cells: 18 nCPM
  • fallopian tube ciliated cells: 17 nCPM
  • papillary tip epithelial cells: 14 nCPM
  • renal collecting duct intercalated cells: 11 nCPM
  • proximal tubule cells: 11 nCPM

Immune cell

  • NK-cell: 59 nTPM
  • myeloid DC: 55 nTPM
  • memory B-cell: 54 nTPM
  • naive B-cell: 43 nTPM
  • intermediate monocyte: 38 nTPM
  • non-classical monocyte: 36 nTPM

Brain region

  • midbrain: 25 nTPM
  • hippocampal formation: 24 nTPM
  • hypothalamus: 24 nTPM
  • pons: 23 nTPM
  • medulla oblongata: 22 nTPM
  • thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
1.08
DepMap mean gene effect
-1.36
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR77 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR77 as an antibody target. Whether an autoantibody or antibody against WDR77 could matter depends on whether native WDR77 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR77 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR77 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR77. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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