Seroatlas · Human Serome Atlas

WRAP53

Telomerase Cajal body protein 1

Also known as: FLJ10385, TCAB1, TCAB1_HUMAN, WDR79

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUR4
Gene
WRAP53
Ensembl
ENSG00000141499
Chromosome
17
Canonical length
548 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>Q9BUR4|WRAP53
     1  MKTLETQPLA PDCCPSDQDP APAHPSPHAS PMNKNADSEL MPPPPERGDP PRLSPDPVAG
    61  SAVSQELREG DPVSLSTPLE TEFGSPSELS PRIEEQELSE NTSLPAEEAN GSLSEEEANG
   121  PELGSGKAME DTSGEPAAED EGDTAWNYSF SQLPRFLSGS WSEFSTQPEN FLKGCKWAPD
   181  GSCILTNSAD NILRIYNLPP ELYHEGEQVE YAEMVPVLRM VEGDTIYDYC WYSLMSSAQP
   241  DTSYVASSSR ENPIHIWDAF TGELRASFRA YNHLDELTAA HSLCFSPDGS QLFCGFNRTV
   301  RVFSTARPGR DCEVRATFAK KQGQSGIISC IAFSPAQPLY ACGSYGRSLG LYAWDDGSPL
   361  ALLGGHQGGI THLCFHPDGN RFFSGARKDA ELLCWDLRQS GYPLWSLGRE VTTNQRIYFD
   421  LDPTGQFLVS GSTSGAVSVW DTDGPGNDGK PEPVLSFLPQ KDCTNGVSLH PSLPLLATAS
   481  GQRVFPEPTE SGDEGEELGL PLLSTRHVHL ECRLQLWWCG GAPDSSIPDD HQGEKGQGGT
   541  EGGVGELI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WRAP53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 13 nTPM
  • thymus: 7.4 nTPM
  • spleen: 6.6 nTPM
  • choroid plexus: 6.5 nTPM
  • skeletal muscle: 5.9 nTPM
  • lymph node: 5.8 nTPM

Single-cell type

  • respiratory ciliated cells: 62 nCPM
  • fallopian tube ciliated cells: 54 nCPM
  • endometrial ciliated cells: 30 nCPM
  • gastric progenitor cells: 27 nCPM
  • ependymal cells: 25 nCPM
  • oocytes: 23 nCPM

Immune cell

  • basophil: 34 nTPM
  • T-reg: 9.9 nTPM
  • plasmacytoid DC: 7.3 nTPM
  • MAIT T-cell: 6.9 nTPM
  • memory CD8 T-cell: 6.5 nTPM
  • intermediate monocyte: 6.4 nTPM

Brain region

  • choroid plexus: 3.8 nTPM
  • medulla oblongata: 3.7 nTPM
  • midbrain: 3.7 nTPM
  • white matter: 3 nTPM
  • spinal cord: 2.8 nTPM
  • basal ganglia: 2.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WRAP53.

Disease | AllUniProt

Conditions WRAP53 is implicated in, by any mechanism.

  • Dyskeratosis congenita, autosomal recessive, 3 (DKCB3) MIM:613988

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 571 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on WRAP53 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WRAP53 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WRAP53 as an antibody target. Whether an autoantibody or antibody against WRAP53 could matter depends on whether native WRAP53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WRAP53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WRAP53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WRAP53. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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