Seroatlas · Human Serome Atlas

ZNRD2

Protein ZNRD2

Also known as: p27, SSSCA1, ZNRD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60232
Gene: ZNRD2
Ensembl: ENSG00000173465
Chromosome: 11
Canonical length: 199 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>O60232|ZNRD2
     1  MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG ETCADCGTIL
    61  LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ LASASELPLG SRPAPQPPVP
   121  RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM ACTQTALLQK LTWASAELGS STSLETSIQL
   181  CGLIRACAEA LRSLQQLQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNRD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 98 nTPM
pancreas: 58 nTPM
blood vessel: 48 nTPM
bone marrow: 46 nTPM
salivary gland: 43 nTPM
heart muscle: 42 nTPM

Single-cell type

late primary spermatocytes: 188 nCPM
early spermatids: 125 nCPM
esophageal basal cells: 116 nCPM
esophageal suprabasal cells: 115 nCPM
late spermatids: 103 nCPM
extravillous trophoblasts: 100 nCPM

Immune cell

memory B-cell: 104 nTPM
naive B-cell: 90 nTPM
plasmacytoid DC: 86 nTPM
NK-cell: 86 nTPM
T-reg: 70 nTPM
naive CD4 T-cell: 66 nTPM

Brain region

cerebral cortex: 47 nTPM
hippocampal formation: 46 nTPM
white matter: 39 nTPM
midbrain: 36 nTPM
basal ganglia: 36 nTPM
medulla oblongata: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

ZNRD2-like, N-terminal domain
UPF0148 domain-containing protein
Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNRD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNRD2 as an antibody target. Whether an autoantibody or antibody against ZNRD2 could matter depends on whether native ZNRD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNRD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome.

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