Seroatlas · Human Serome Atlas

TUBA1B

Tubulin alpha-1B chain

Also known as: K-ALPHA-1, TBA1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P68363
Gene
TUBA1B
Ensembl
ENSG00000123416
Chromosome
12
Canonical length
451 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Primary cilium

OverviewNCBI Gene

Enables several functions, including GTP binding activity; GTPase activity; and ubiquitin protein ligase binding activity. A structural constituent of cytoskeleton. Involved in microtubule cytoskeleton organization. Located in cilium and microtubule. Is active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>P68363|TUBA1B
     1  MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK
    61  HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD
   121  RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA
   181  VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA
   241  SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN
   301  QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRS IQFVDWCPTG FKVGINYQPP
   361  TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE
   421  AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBA1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
1,800 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 1,800 nTPM
  • spinal cord: 1,480 nTPM
  • thymus: 1,451 nTPM
  • bone marrow: 1,407 nTPM
  • hypothalamus: 1,113 nTPM
  • amygdala: 1,071 nTPM

Single-cell type

  • extravillous trophoblasts: 3,079 nCPM
  • hofbauer cells: 3,042 nCPM
  • megakaryocytes: 2,862 nCPM
  • esophageal basal cells: 1,766 nCPM
  • migrating cytotrophoblasts: 1,656 nCPM
  • erythrocyte progenitors: 1,492 nCPM

Immune cell

  • non-classical monocyte: 1,112 nTPM
  • intermediate monocyte: 1,022 nTPM
  • total PBMC: 731 nTPM
  • plasmacytoid DC: 633 nTPM
  • myeloid DC: 633 nTPM
  • eosinophil: 412 nTPM

Brain region

  • cerebral cortex: 1,545 nTPM
  • medulla oblongata: 1,354 nTPM
  • pons: 1,308 nTPM
  • hypothalamus: 1,277 nTPM
  • thalamus: 1,246 nTPM
  • midbrain: 1,220 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBA1B.

Disease | ImmuneIEDB

Conditions an epitope on TUBA1B was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
5.41
DepMap mean gene effect
-1.36
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBA1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBA1B as an antibody target. Whether an autoantibody or antibody against TUBA1B could matter depends on whether native TUBA1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBA1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBA1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUBA1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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