Seroatlas · Human Serome Atlas

TLE2

Transducin-like enhancer protein 2

Also known as: ESG, ESG2, FLJ41188, GRG2, TLE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q04725
Gene: TLE2
Ensembl: ENSG00000065717
Chromosome: 19
Canonical length: 743 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Focal adhesion sites
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

743 residues, UniProt reviewed canonical sequence.

>Q04725|TLE2
     1  MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY
    61  VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS
   121  LIGQQLQPLS HHAPPVPLTP RPAGLVGGSA TGLLALSGAL AAQAQLAAAV KEDRAGVEAE
   181  GSRVERAPSR SASPSPPESL VEEERPSGPG GGGKQRADEK EPSGPYESDE DKSDYNLVVD
   241  EDQPSEPPSP ATTPCGKVPI CIPARRDLVD SPASLASSLG SPLPRAKELI LNDLPASTPA
   301  SKSCDSSPPQ DASTPGPSSA SHLCQLAAKP APSTDSVALR SPLTLSSPFT TSFSLGSHST
   361  LNGDLSVPSS YVSLHLSPQV SSSVVYGRSP VMAFESHPHL RGSSVSSSLP SIPGGKPAYS
   421  FHVSADGQMQ PVPFPSDALV GAGIPRHARQ LHTLAHGEVV CAVTISGSTQ HVYTGGKGCV
   481  KVWDVGQPGA KTPVAQLDCL NRDNYIRSCK LLPDGRSLIV GGEASTLSIW DLAAPTPRIK
   541  AELTSSAPAC YALAVSPDAK VCFSCCSDGN IVVWDLQNQT MVRQFQGHTD GASCIDISDY
   601  GTRLWTGGLD NTVRCWDLRE GRQLQQHDFS SQIFSLGHCP NQDWLAVGME SSNVEILHVR
   661  KPEKYQLHLH ESCVLSLKFA SCGRWFVSTG KDNLLNAWRT PYGASIFQSK ESSSVLSCDI
   721  SRNNKYIVTG SGDKKATVYE VVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 286 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 286 nTPM
salivary gland: 81 nTPM
heart muscle: 74 nTPM
thyroid gland: 71 nTPM
urinary bladder: 70 nTPM
fallopian tube: 64 nTPM

Single-cell type

oocytes: 180 nCPM
renal collecting duct principal cells: 84 nCPM
papillary tip epithelial cells: 81 nCPM
urothelial cells: 80 nCPM
prostatic club cells: 80 nCPM
salivary duct cells: 75 nCPM

Immune cell

memory B-cell: 1.7 nTPM
naive CD4 T-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM
MAIT T-cell: 0.9 nTPM
memory CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

cerebellum: 129 nTPM
hypothalamus: 46 nTPM
pons: 45 nTPM
medulla oblongata: 34 nTPM
white matter: 34 nTPM
midbrain: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 0.83
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription corepressor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLE2 as an antibody target. Whether an autoantibody or antibody against TLE2 could matter depends on whether native TLE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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