Seroatlas · Human Serome Atlas

TUBD1

Tubulin delta chain

Also known as: FLJ12709, TBD_HUMAN, TUBD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJT1
Gene: TUBD1
Ensembl: ENSG00000108423
Chromosome: 17
Canonical length: 453 aa
Protein class: FDA approved drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization; mitotic cell cycle; and positive regulation of smoothened signaling pathway. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q9UJT1|TUBD1
     1  MSIVTVQLGQ CGNQIGFEVF DALLSDSHSS QGLCSMRENE AYQASCKERF FSEEENGVPI
    61  ARAVLVDMEP KVINQMLSKA AQSGQWKYGQ HACFCQKQGS GNNWAYGYSV HGPRHEESIM
   121  NIIRKEVEKC DSFSGFFIIM SMAGGTGSGL GAFVTQNLED QYSNSLKMNQ IIWPYGTGEV
   181  IVQNYNSILT LSHLYRSSDA LLLHENDAIH KICAKLMNIK QISFSDINQV LAHQLGSVFQ
   241  PTYSAESSFH YRRNPLGDLM EHLVPHPEFK MLSVRNIPHM SENSLAYTTF TWAGLLKHLR
   301  QMLISNAKME EGIDRHVWPP LSGLPPLSKM SLNKDLHFNT SIANLVILRG KDVQSADVEG
   361  FKDPALYTSW LKPVNAFNVW KTQRAFSKYE KSAVLVSNSQ FLVKPLDMIV GKAWNMFASK
   421  AYIHQYTKFG IEEEDFLDSF TSLEQVVASY CNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

esophagus: 10 nTPM
epididymis: 8.5 nTPM
vagina: 8.2 nTPM
ovary: 8 nTPM
tonsil: 7.7 nTPM
cerebellum: 7.6 nTPM

Single-cell type

myonuclei: 103 nCPM
endometrial glandular cells: 96 nCPM
esophageal apical cells: 72 nCPM
epididymal basal cells: 70 nCPM
undifferentiated spermatogonia: 49 nCPM
neutrophils: 43 nCPM

Immune cell

naive CD4 T-cell: 18 nTPM
T-reg: 17 nTPM
eosinophil: 16 nTPM
naive CD8 T-cell: 15 nTPM
memory CD4 T-cell: 14 nTPM
MAIT T-cell: 13 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 20 nTPM
midbrain: 18 nTPM
medulla oblongata: 18 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.39
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBD1 as an antibody target. Whether an autoantibody or antibody against TUBD1 could matter depends on whether native TUBD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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