Seroatlas · Human Serome Atlas

RC3H2

Roquin-2

Also known as: FLJ20301, FLJ20713, MNAB, RC3H2_HUMAN, RNF164

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBD1
Gene
RC3H2
Ensembl
ENSG00000056586
Chromosome
9
Canonical length
1191 aa
Protein class
Enzymes, Predicted intracellular proteins, Transcription factors
Subcellular location
Vesicles

OverviewNCBI Gene

Enables DNA binding activity; RNA binding activity; and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Located in cell surface; intracellular membrane-bounded organelle; and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1191 residues, UniProt reviewed canonical sequence.

>Q9HBD1|RC3H2
     1  MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD
    61  IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS
   121  LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL
   181  WAAVRARGCQ FLGPAMQEEA LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG
   241  HVVQLLYRAS CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW
   301  SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL RPHLELLANI
   361  DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH ETPQPQPNSK YKTSMCRDLR
   421  QQGGCPRGTN CTFAHSQEEL EKYRLRNKKI NATVRTFPLL NKVGVNNTVT TTAGNVISVI
   481  GSTETTGKIV PSTNGISNAE NSVSQLISRS TDSTLRALET VKKVGKVGAN GQNAAGPSAD
   541  SVTENKIGSP PKTPVSNVAA TSAGPSNVGT ELNSVPQKSS PFLTRVPVYP PHSENIQYFQ
   601  DPRTQIPFEV PQYPQTGYYP PPPTVPAGVA PCVPRFVRSN NVPESSLPPA SMPYADHYST
   661  FSPRDRMNSS PYQPPPPQPY GPVPPVPSGM YAPVYDSRRI WRPPMYQRDD IIRSNSLPPM
   721  DVMHSSVYQT SLRERYNSLD GYYSVACQPP SEPRTTVPLP REPCGHLKTS CEEQIRRKPD
   781  QWAQYHTQKA PLVSSTLPVA TQSPTPPSPL FSVDFRADFS ESVSGTKFEE DHLSHYSPWS
   841  CGTIGSCINA IDSEPKDVIA NSNAVLMDLD SGDVKRRVHL FETQRRTKEE DPIIPFSDGP
   901  IISKWGAISR SSRTGYHTTD PVQATASQGS ATKPISVSDY VPYVNAVDSR WSSYGNEATS
   961  SAHYVERDRF IVTDLSGHRK HSSTGDLLSL ELQQAKSNSL LLQREANALA MQQKWNSLDE
  1021  GRHLTLNLLS KEIELRNGEL QSDYTEDATD TKPDRDIELE LSALDTDEPD GQSEPIEEIL
  1081  DIQLGISSQN DQLLNGMAVE NGHPVQQHQK EPPKQKKQSL GEDHVILEEQ KTILPVTSCF
  1141  SQPLPVSISN ASCLPITTSV SAGNLILKTH VMSEDKNDFL KPVANGKMVN S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RC3H2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 31 nTPM
  • thymus: 18 nTPM
  • lymph node: 17 nTPM
  • tonsil: 16 nTPM
  • parathyroid gland: 15 nTPM
  • retina: 15 nTPM

Single-cell type

  • lactotrophs: 172 nCPM
  • hematopoietic stem cells: 149 nCPM
  • thyrotrophs: 139 nCPM
  • sertoli cells: 116 nCPM
  • somatotrophs: 115 nCPM
  • platelets: 113 nCPM

Immune cell

  • basophil: 9.8 nTPM
  • neutrophil: 8 nTPM
  • intermediate monocyte: 7.3 nTPM
  • non-classical monocyte: 6.7 nTPM
  • plasmacytoid DC: 6.5 nTPM
  • gdT-cell: 6.1 nTPM

Brain region

  • cerebellum: 55 nTPM
  • basal ganglia: 49 nTPM
  • cerebral cortex: 49 nTPM
  • white matter: 46 nTPM
  • hippocampal formation: 45 nTPM
  • thalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
2.45
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RC3H2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RC3H2 as an antibody target. Whether an autoantibody or antibody against RC3H2 could matter depends on whether native RC3H2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RC3H2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RC3H2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RC3H2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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