NOTCH1, EGF-like calcium-binding domain
IPR049883
Definition
This entry represents the EGF-like domains found in Neurogenic locus notch homolog protein 1 (NOTCH1) and related proteins such as protein kinase C-binding protein NELL2, Uromodulin and others. The EGF-like domains in NOTCH1 perform multiple functions and constitute crucial elements of the Notch signalling system. They play a role in dimer formation. They also serve as a protection against proteases, including TNF-alpha converting enzyme, which prevents Notch1 from ligand-independent activation PMID:15561108.
73 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (73 proteins: gene, accession, name)
- ADGRE1
- ADGRE2
- ADGRE3
- ADGRE4P
- ADGRE5
- ADGRL4
- BMP1
- CCBE1
- CD93
- COMP
- CRELD1
- CRELD2
- CRTAC1
- CUBN
- EFEMP1
- EFEMP2
- EGF
- EGFL6
- EGFL8
- FAT4
- FBLN1
- FBLN2
- FBLN5
- FBLN7
- FBN1
- FBN2
- FBN3
- GAS6
- HEG1
- HMCN1
- HMCN2
- JAG2
- LDLR
- LRP1
- LRP1B
- LRP2
- LRP8
- LTBP1
- LTBP2
- LTBP3
- LTBP4
- MASP2
- MATN2
- MATN3
- MEGF6
- MEGF8
- NBPF26
- NELL1
- NELL2
- NID1
- NID2
- NOTCH1
- NOTCH2
- NOTCH2NLA
- NOTCH2NLB
- NOTCH2NLC
- NOTCH2NLR
- NOTCH3
- NOTCH4
- NPNT
- PROS1
- SCUBE1
- SCUBE2
- SCUBE3
- SUSD1
- SVEP1
- THBD
- THBS3
- TLL2
- TPO
- UMOD
- UMODL1
- VLDLR
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