CRTAC1

Protein identityUniProt · HPA

UniProt accession

Q9NQ79

Gene

CRTAC1

Ensembl

ENSG00000095713

Chromosome

10

Canonical length

661 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

661 residues, UniProt reviewed canonical sequence.

>Q9NQ79|CRTAC1
     1  MAPSADPGMS RMLPFLLLLW FLPITEGSQR AEPMFTAVTN SVLPPDYDSN PTQLNYGVAV
    61  TDVDHDGDFE IVVAGYNGPN LVLKYDRAQK RLVNIAVDER SSPYYALRDR QGNAIGVTAC
   121  DIDGDGREEI YFLNTNNAFS GVATYTDKLF KFRNNRWEDI LSDEVNVARG VASLFAGRSV
   181  ACVDRKGSGR YSIYIANYAY GNVGPDALIE MDPEASDLSR GILALRDVAA EAGVSKYTGG
   241  RGVSVGPILS SSASDIFCDN ENGPNFLFHN RGDGTFVDAA ASAGVDDPHQ HGRGVALADF
   301  NRDGKVDIVY GNWNGPHRLY LQMSTHGKVR FRDIASPKFS MPSPVRTVIT ADFDNDQELE
   361  IFFNNIAYRS SSANRLFRVI RREHGDPLIE ELNPGDALEP EGRGTGGVVT DFDGDGMLDL
   421  ILSHGESMAQ PLSVFRGNQG FNNNWLRVVP RTRFGAFARG AKVVLYTKKS GAHLRIIDGG
   481  SGYLCEMEPV AHFGLGKDEA SSVEVTWPDG KMVSRNVASG EMNSVLEILY PRDEDTLQDP
   541  APLECGQGFS QQENGHCMDT NECIQFPFVC PRDKPVCVNT YGSYRCRTNK KCSRGYEPNE
   601  DGTACVGTLG QSPGPRPTTP TAAAATAAAA AAAGAATAAP VLVDGDLNLG SVVKESCEPS
   661  C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRTAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

62 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.77

gnomAD pLI

0

gnomAD missense Z

1.18

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axonal fasciculation
• olfactory bulb development
• regulation of synapse assembly

Molecular functions

• calcium ion binding

Cellular components

• extracellular exosome
• glutamatergic synapse
• growth cone
• postsynaptic density

Protein domainsUniProt · Pfam · InterPro

• EGF-like calcium-binding domain
• FG-GAP repeat
• EGF-like calcium-binding, conserved site
• Integrin alpha, N-terminal
• NOTCH1, EGF-like calcium-binding domain
• Calcium-binding EGF domain
• FG-GAP-like repeat
• ASPIC/UnbV
• Cartilage acidic protein 1
• ASPIC and UnbV

KeywordsUniProt

• Disulfide bond
• EGF-like domain
• Extracellular matrix
• Glycoprotein
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of CRTAC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAPRE2