Glycoside hydrolase superfamily
IPR017853
Definition
This entry represents the catalytic TIM β/α barrel common to many different families of glycosyl hydrolases found in all groups of organisms including viruses and Gene Transfer Agents (GTA) PMID:11382219. In the GTA of Rhodobacter capsulatus (Rhodopseudomonas capsulata) a glycosyl hydrolase domain is associated with ORFg15 (RCAP_rcc01698) [[swissprot:D5AU04], see Fig.1, in [cite:PMID:12399927]]. Structures have been determined for several proteins containing this glycosyl hydrolase domain, including family 13 glycosyl hydrolases [cazy:GH13] (such as alpha-amylase) PMID:11914097, beta-glycanases PMID:14668328, family 1 glycosyl hydrolases [cazy:GH1] (such as beta-glucosidase) PMID:10978344, type II chitinases [cazy:GH18] PMID:11846790, 1,4-beta-N-acetylmuraminidases [cazy:GH22] PMID:11427528, and beta-N-acetylhexosaminidases [cazy:CBM5] PMID:12171933. O-Glycosyl hydrolases ([ec:3.2.1.]) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [[cite:PMID:7624375], [cite:PMID:8535779]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.
54 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...