FUCA2

Protein identityUniProt · HPA

UniProt accession

Q9BTY2

Gene

FUCA2

Ensembl

ENSG00000001036

Chromosome

6

Canonical length

467 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to blood

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q9BTY2|FUCA2
     1  MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF DQAKFGIFIH
    61  WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY EDFGPLFTAK FFNANQWADI
   121  FQASGAKYIV LTSKHHEGFT LWGSEYSWNW NAIDEGPKRD IVKELEVAIR NRTDLRFGLY
   181  YSLFEWFHPL FLEDESSSFH KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS
   241  TGFLAWLYNE SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL
   301  SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE ERLRQMGSWL
   361  KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL KWPTSGQLFL GHPKAILGAT
   421  EVKLLGHGQP LNWISLEQNG IMVELPQLTI HQMPCKWGWA LALTNVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUCA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

156 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.9

gnomAD pLI

0

gnomAD missense Z

0.82

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fucose metabolic process
• glycoside catabolic process
• regulation of entry of bacterium into host cell
• response to bacterium

Molecular functions

• alpha-L-fucosidase activity

Cellular components

• azurophil granule lumen
• endoplasmic reticulum lumen
• extracellular exosome
• extracellular region
• extracellular space
• lysosome

Protein domainsUniProt · Pfam · InterPro

• Glycoside hydrolase, family 29
• Glycosyl hydrolase, all-beta
• Alpha-L-fucosidase, metazoa-type
• Glycoside hydrolase superfamily
• Glycoside hydrolase, family 29, conserved site
• Alpha-L-fucosidase, C-terminal
• Glycoside hydrolase family 29, N-terminal
• Alpha-L-fucosidase
• Alpha-L-fucosidase C-terminal domain

KeywordsUniProt

• Glycoprotein
• Glycosidase
• Hydrolase
• Phosphoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of FUCA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CANX