SLC3A2

Protein identityUniProt · HPA

UniProt accession

P08195

Gene

SLC3A2

Ensembl

ENSG00000168003

Chromosome

11

Canonical length

630 aa

Protein class

Cancer-related genes, CD markers, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>P08195|SLC3A2
     1  MELQPPEASI AVVSIPRQLP GSHSEAGVQG LSAGDDSELG SHCVAQTGLE LLASGDPLPS
    61  ASQNAEMIET GSDCVTQAGL QLLASSDPPA LASKNAEVTG TMSQDTEVDM KEVELNELEP
   121  EKQPMNAASG AAMSLAGAEK NGLVKIKVAE DEAEAAAAAK FTGLSKEELL KVAGSPGWVR
   181  TRWALLLLFW LGWLGMLAGA VVIIVRAPRC RELPAQKWWH TGALYRIGDL QAFQGHGAGN
   241  LAGLKGRLDY LSSLKVKGLV LGPIHKNQKD DVAQTDLLQI DPNFGSKEDF DSLLQSAKKK
   301  SIRVILDLTP NYRGENSWFS TQVDTVATKV KDALEFWLQA GVDGFQVRDI ENLKDASSFL
   361  AEWQNITKGF SEDRLLIAGT NSSDLQQILS LLESNKDLLL TSSYLSDSGS TGEHTKSLVT
   421  QYLNATGNRW CSWSLSQARL LTSFLPAQLL RLYQLMLFTL PGTPVFSYGD EIGLDAAALP
   481  GQPMEAPVML WDESSFPDIP GAVSANMTVK GQSEDPGSLL SLFRRLSDQR SKERSLLHGD
   541  FHAFSAGPGL FSYIRHWDQN ERFLVVLNFG DVGLSAGLQA SDLPASASLP AKADLLLSTQ
   601  PGREEGSPLE LERLKLEPHE GLLLRFPYAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC3A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

178 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for SLC3A2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.91

gnomAD pLI

0

gnomAD missense Z

1.15

DepMap mean gene effect

-0.5

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amino acid transport
• calcium ion transport
• carbohydrate metabolic process
• isoleucine transport
• L-alanine import across plasma membrane
• L-histidine transport
• L-leucine import across plasma membrane
• L-leucine transport
• methionine transport
• phenylalanine transport
• proline transport
• response to exogenous dsRNA
• symbiont entry into host cell
• thyroid hormone transport
• tryptophan transport
• tyrosine transport
• valine transport

Molecular functions

• aromatic amino acid transmembrane transporter activity
• cadherin binding
• double-stranded RNA binding
• exogenous protein binding
• L-alanine transmembrane transporter activity
• L-leucine transmembrane transporter activity
• neutral L-amino acid transmembrane transporter activity
• protein heterodimerization activity
• protein homodimerization activity
• RNA binding
• virus receptor activity

Cellular components

• amino acid transport complex
• anchoring junction
• apical plasma membrane
• basal plasma membrane
• basolateral plasma membrane
• cell surface
• extracellular exosome
• lysosomal membrane
• melanosome
• membrane
• nucleoplasm
• plasma membrane
• synapse
• apical pole of neuron

Protein domainsUniProt · Pfam · InterPro

• Glycosyl hydrolase family 13, catalytic domain
• Glycosyl hydrolase, all-beta
• Glycoside hydrolase superfamily
• Alpha amylase, catalytic domain
• Solute carrier family 3 member 2, N-terminal domain
• Amino acid transporter heavy chain SLC3A2
• Solute carrier family 3 member 2 N-terminus

KeywordsUniProt

• Acetylation
• Amino-acid transport
• Cell junction
• Cell membrane
• Disulfide bond
• Glycoprotein
• Host cell receptor for virus entry
• Isopeptide bond
• Lysosome
• Membrane
• Phosphoprotein
• Receptor
• Signal-anchor
• Transmembrane
• Transmembrane helix
• Transport
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of SLC3A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ICAM1
• LAPTM4B
• TLCD3A
• ATP1A1
• CANX
• GPR37
• RAB11A
• SLC7A11
• SLC7A5
• SLC7A6
• SLC7A7