Seroatlas · Human Serome Atlas

AMY1A

Alpha-amylase 1A

Also known as: AMY1, AMY1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DUB6
Gene: AMY1A
Ensembl: ENSG00000237763
Chromosome: 1
Canonical length: 511 aa
Protein class: Enzymes, Metabolic proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Cytosol
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

511 residues, UniProt reviewed canonical sequence.

>P0DUB6|AMY1A
     1  MKLFWLLFTI GFCWAQYSSN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP
    61  NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN
   121  AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLSGL
   181  LDLALGKDYV RSKIAEYMNH LIDIGVAGFR IDASKHMWPG DIKAILDKLH NLNSNWFPEG
   241  SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG
   301  FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP
   361  RYFENGKDVN DWVGPPNDNG VTKEVTINPD TTCGNDWVCE HRWRQIRNMV NFRNVVDGQP
   421  FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT FSLTLQTGLP AGTYCDVISG DKINGNCTGI
   481  KIYVSDDGKA HFSISNSAED PFIAIHAESK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMY1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.2
Highest tissue expression: 7,769 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 7,769 nTPM
cervix: 25 nTPM
pancreas: 2 nTPM
tonsil: 1.8 nTPM
fallopian tube: 1.2 nTPM
bone marrow: 0.8 nTPM

Single-cell type

salivary acinar cells: 14 nCPM
salivary myoepithelial cells: 4.8 nCPM
late spermatids: 1.1 nCPM
respiratory ciliated cells: 0.9 nCPM
early spermatids: 0.5 nCPM
neutrophils: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -0.05

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMY1A as an antibody target. Whether an autoantibody or antibody against AMY1A could matter depends on whether native AMY1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMY1A is annotated as secreted, so native AMY1A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AMY1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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