CHI3L2

Protein identityUniProt · HPA

UniProt accession

Q15782

Gene

CHI3L2

Ensembl

ENSG00000064886

Chromosome

1

Canonical length

390 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q15782|CHI3L2
     1  MGATTMDQKS LWAGVVVLLL LQGGSAYKLV CYFTNWSQDR QEPGKFTPEN IDPFLCSHLI
    61  YSFASIENNK VIIKDKSEVM LYQTINSLKT KNPKLKILLS IGGYLFGSKG FHPMVDSSTS
   121  RLEFINSIIL FLRNHNFDGL DVSWIYPDQK ENTHFTVLIH ELAEAFQKDF TKSTKERLLL
   181  TAGVSAGRQM IDNSYQVEKL AKDLDFINLL SFDFHGSWEK PLITGHNSPL SKGWQDRGPS
   241  SYYNVEYAVG YWIHKGMPSE KVVMGIPTYG HSFTLASAET TVGAPASGPG AAGPITESSG
   301  FLAYYEICQF LKGAKITRLQ DQQVPYAVKG NQWVGYDDVK SMETKVQFLK NLNLGGAMIW
   361  SIDMDDFTGK SCNQGPYPLV QAVKRSLGSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHI3L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

187 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for CHI3L2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.45

gnomAD pLI

0

gnomAD missense Z

-0.43

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate metabolic process
• chitin catabolic process

Molecular functions

• carbohydrate binding
• chitin binding
• hydrolase activity

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Glycoside hydrolase family 18, catalytic domain
• Chitinase II/V-like, catalytic domain
• Glycoside hydrolase superfamily
• Chitinase insertion domain superfamily
• Glycosyl hydrolase family 18
• Glycosyl hydrolases family 18

KeywordsUniProt

• Chitin-binding
• Disulfide bond
• Glycoprotein
• Hydrolase
• Lectin
• Secreted
• Signal