Seroatlas · Human Serome Atlas

GBA3

Cytosolic beta-glucosidase

Also known as: GBA3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H227
Gene: GBA3
Canonical length: 469 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GBA3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q9H227|GBA3
     1  MAFPAGFGWA AATAAYQVEG GWDADGKGPC VWDTFTHQGG ERVFKNQTGD VACGSYTLWE
    61  EDLKCIKQLG LTHYRFSLSW SRLLPDGTTG FINQKGIDYY NKIIDDLLKN GVTPIVTLYH
   121  FDLPQTLEDQ GGWLSEAIIE SFDKYAQFCF STFGDRVKQW ITINEANVLS VMSYDLGMFP
   181  PGIPHFGTGG YQAAHNLIKA HARSWHSYDS LFRKKQKGMV SLSLFAVWLE PADPNSVSDQ
   241  EAAKRAITFH LDLFAKPIFI DGDYPEVVKS QIASMSQKQG YPSSRLPEFT EEEKKMIKGT
   301  ADFFAVQYYT TRLIKYQENK KGELGILQDA EIEFFPDPSW KNVDWIYVVP WGVCKLLKYI
   361  KDTYNNPVIY ITENGFPQSD PAPLDDTQRW EYFRQTFQEL FKAIQLDKVN LQVYCAWSLL
   421  DNFEWNQGYS SRFGLFHVDF EDPARPRVPY TSAKEYAKII RNNGLEAHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.19
Highest tissue expression: 211 nTPM

Expression across tissuesHPA

Tissue

liver: 211 nTPM
kidney: 167 nTPM
duodenum: 161 nTPM
small intestine: 153 nTPM
gallbladder: 12 nTPM
colon: 8.5 nTPM

Single-cell type

enterocytes: 526 nCPM
endometrial ciliated cells: 158 nCPM
endometrial luminal cells: 158 nCPM
hepatocytes: 117 nCPM
enteric transient amplifying cells: 75 nCPM
endometrial glandular cells: 71 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.6 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM
hypothalamus: 0.2 nTPM
midbrain: 0.2 nTPM
spinal cord: 0.2 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GBA3 as an antibody target. Whether an autoantibody or antibody against GBA3 could matter depends on whether native GBA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GBA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GBA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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