Seroatlas · Human Serome Atlas

HYAL3

Hyaluronidase-3

Also known as: HYAL3_HUMAN, LUCA-3, LUCA14, Minna14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43820
Gene
HYAL3
Ensembl
ENSG00000186792
Chromosome
3
Canonical length
417 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>O43820|HYAL3
     1  MTTQLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCEARFGVHL PLNALGIIAN
    61  RGQHFHGQNM TIFYKNQLGL YPYFGPRGTA HNGGIPQALP LDRHLALAAY QIHHSLRPGF
   121  AGPAVLDWEE WCPLWAGNWG RRRAYQAASW AWAQQVFPDL DPQEQLYKAY TGFEQAARAL
   181  MEDTLRVAQA LRPHGLWGFY HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA
   241  LFPSIYLPPR LPPAHHQAFV RHRLEEAFRV ALVGHRHPLP VLAYVRLTHR RSGRFLSQDD
   301  LVQSIGVSAA LGAAGVVLWG DLSLSSSEEE CWHLHDYLVD TLGPYVINVT RAAMACSHQR
   361  CHGHGRCARR DPGQMEAFLH LWPDGSLGDW KSFSCHCYWG WAGPTCQEPR PGPKEAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HYAL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 34 nTPM
  • testis: 13 nTPM
  • cerebellum: 7.1 nTPM
  • cerebral cortex: 6.8 nTPM
  • basal ganglia: 5.1 nTPM
  • liver: 5 nTPM

Single-cell type

  • late spermatids: 436 nCPM
  • early spermatids: 97 nCPM
  • megakaryocytes: 25 nCPM
  • late primary spermatocytes: 24 nCPM
  • megakaryocyte progenitors: 22 nCPM
  • platelets: 17 nCPM

Immune cell

  • eosinophil: 55 nTPM
  • basophil: 33 nTPM
  • myeloid DC: 8.2 nTPM
  • classical monocyte: 4.1 nTPM
  • memory CD4 T-cell: 4.1 nTPM
  • naive B-cell: 2.9 nTPM

Brain region

  • pons: 13 nTPM
  • cerebral cortex: 12 nTPM
  • cerebellum: 11 nTPM
  • medulla oblongata: 11 nTPM
  • white matter: 9 nTPM
  • thalamus: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
1.1
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HYAL3 as an antibody target. Whether an autoantibody or antibody against HYAL3 could matter depends on whether native HYAL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HYAL3 is annotated at the cell surface, where native HYAL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HYAL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HYAL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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