Seroatlas · Human Serome Atlas

MYORG

Myogenesis-regulating glycosidase

Also known as: KIAA1161, MYORG_HUMAN, NET37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NSJ0
Gene
MYORG
Ensembl
ENSG00000164976
Chromosome
9
Canonical length
714 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Involved in skeletal muscle fiber development. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Implicated in basal ganglia calcification. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

714 residues, UniProt reviewed canonical sequence.

>Q6NSJ0|MYORG
     1  MLQNPQEKSQ AYPRRRRPGC YAYRQNPEAI AAAAMYTFLP DNFSPAKPKP SKDLKPLLGS
    61  AVLGLLLVLA AVVAWCYYSV SLRKAERLRA ELLDLKAGGF SIRNQKGEQV FRLAFRSGAL
   121  DLDSCSRDGA LLGCSLTADG LPLHFFIQTV RPKDTVMCYR VRWEEAAPGR AVEHAMFLGD
   181  AAAHWYGGAE MRTQHWPIRL DGQQEPQPFV TSDVYSSDAA FGGILERYWL SSRAAAIKVN
   241  DSVPFHLGWN STERSLRLQA RYHDTPYKPP AGRAAAPELS YRVCVGSDVT SIHKYMVRRY
   301  FNKPSRVPAP EAFRDPIWST WALYGRAVDQ DKVLRFAQQI RLHHFNSSHL EIDDMYTPAY
   361  GDFDFDEVKF PNASDMFRRL RDAGFRVTLW VHPFVNYNSS RFGEGVEREL FVREPTGRLP
   421  ALVRWWNGIG AVLDFTHPKA RDWFQGHLRR LRSRYSVASF KFDAGEVSYL PRDFSTYRPL
   481  PDPSVWSRRY TEMALPFFSL AEVRVGYQSQ NISCFFRLVD RDSVWGYDLG LRSLIPAVLT
   541  VSMLGYPFIL PDMVGGNAVP QRTAGGDVPE RELYIRWLEV AAFMPAMQFS IPPWRYDAEV
   601  VAIAQKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI DSQFLIGDTL
   661  LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY PVDLDEIAYF TWAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYORG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 79 nTPM
  • liver: 39 nTPM
  • tongue: 37 nTPM
  • basal ganglia: 30 nTPM
  • cerebral cortex: 27 nTPM
  • duodenum: 26 nTPM

Single-cell type

  • cytotrophoblasts: 73 nCPM
  • enterocytes: 70 nCPM
  • hepatocytes: 59 nCPM
  • colonocytes: 49 nCPM
  • astrocytes: 36 nCPM
  • parietal cells: 35 nCPM

Immune cell

  • gdT-cell: 0.7 nTPM
  • T-reg: 0.6 nTPM
  • MAIT T-cell: 0.5 nTPM
  • basophil: 0.4 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • medulla oblongata: 75 nTPM
  • midbrain: 72 nTPM
  • thalamus: 69 nTPM
  • cerebral cortex: 66 nTPM
  • amygdala: 65 nTPM
  • basal ganglia: 65 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYORG.

Disease | AllUniProt

Conditions MYORG is implicated in, by any mechanism.

  • Basal ganglia calcification, idiopathic, 7, autosomal recessive (IBGC7) MIM:618317

Disease | GeneticClinVar

37 pathogenic / likely-pathogenic of 298 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Basal ganglia calcification, idiopathic, 7, autosomal recessive
  • MYORG-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYORG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYORG as an antibody target. Whether an autoantibody or antibody against MYORG could matter depends on whether native MYORG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYORG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYORG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYORG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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