Seroatlas · Human Serome Atlas

MGAM2

Probable maltase-glucoamylase 2

Also known as: MGAL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M2H8
Gene: MGAM2
Ensembl: ENSG00000257743
Chromosome: 7
Canonical length: 2515 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2515 residues, UniProt reviewed canonical sequence.

>Q2M2H8|MGAM2
     1  MARKLSVLEV LLIIFCLIVV TIDILLLLLV LEETSDTSFT PECPEIPQSE RIDCTPDQEV
    61  TEDICRWQYK CCWSPVADAN VPRCFFPWNW GYEASNGHTN TSTGFTAQLK RLPSPSLFGN
   121  DVATTLFTAE YQTSNRFHFK ITDFNNIRYE VSHENINLVD GIADASNLSY YVEVTDKPFS
   181  IKIMRTSNRR VLLDTSIGPL QFAQQYLQLS FRLPSANVYG LGEHVHQQYR HNMTWKTWPI
   241  FTRDATPTEG MINLYGAHTF FLCLEDARGS SFGVFLMNSN AMEVTLQPAP AITYRTIGGI
   301  LDFYVFLGNT PEQVVQEYLE LVGRPFFPPY WSLGFQLSRR DYGGINKLKE VVSRNRLAEI
   361  PYDVQYSDID YMDGKKDFTV DEVAYSGLPD FVKELHDNGQ KYLIIMNPGI SKNSNYEPYN
   421  NGSLKRVWIL GSNGFAVGEG YPGPTVFPDY TNPVCTEWWT DQVAKFHDHL EFDGVWIEMN
   481  EVSSLLQASN NQCESNNLNF PPFLPRVLDH LLFARTLCMD TEFHGGLHYD IHSLYGHSMA
   541  RTTNLALETI FMNNRSFILS RSTFAGSGKF AAHWLGDNAA TWDDLRWSIP TILEFNLFGI
   601  PMVGANICGY NNNVTEELCR RWMQLGAFYP LPRNHNGPGF RDQDPAAFGV DSLLLKSSRH
   661  YLNIRYTLLP YLYTLFYHAH TRGETVARPL VHEFYQDSAT WDVHEQFLWG PGLLITPVLY
   721  EGVDEVKAYI PDATWYDYET GVAISWRKQL VNMLLPGDKI GLHLRGGYIF PTQKPNTTTE
   781  ASRRNSLGLI IALDYKREAK GELYWDDGVS KDAVTEKKYI LYDFSVTSNH LQAKIINNNY
   841  MDTDNLMFTD ITILGMDKQP ANFIVLLNNV ATSSPSVVYN ASTKVVTITD LQGLVLGQEF
   901  SIRWNLPVSD LEKFNCYPDD PTASEESCRQ RGCLWEDTST PGVPTCYYDT IPNYVASDIQ
   961  YLNTSITADL SLPMAPESAA AAASDSLSAK ISFLHLKVIY HTATMLQVKI YDPTNKRYEV
  1021  PVPLNTPPQP VGDPENRLYD VRIQNNPFGI QIQRKNSSTV IWDSQLPGFI FNDMFLSIST
  1081  RLPSQYIYGF GETEHTTFRR NMNWNTWGMF AHDEPPAYKK NSYGVHPYYM ALEEDGSAHG
  1141  VLLLNSNAMD VTLQPTPALT YRTTGGILDF YIVLGPTPEL VTQQYTELIG RPAMIPYWAL
  1201  GFHLSRYGYQ NDAEISSLYD AMVAAQIPYD VQHVDIDYMN RKLDFTLSAN FQNLSLLIEQ
  1261  MKKNGMRFIL ILDPAISGNE TQYLPFIRGQ ENNVFIKWPD TNDIVWGKVW PDLPNVIVDG
  1321  SLDHETQVKL YRAYVAFPDF FRNSTAAWWK KEIEELYANP REPEKSLKFD GLWIDMNEPS
  1381  NFVDGSVRGC SNEMLNNPPY MPYLESRDKG LSSKTLCMES QQILPDSSPV EHYNVHNLYG
  1441  WSQTRPTYEA VQEVTGQRGV IITRSTFPSS GRWGGHRLGN NTAAWDQLGK SIIGMMEFSL
  1501  FGIPYTGADI CGFFGDAEYE MCVRWMQLGA FYPFSRNHNN IGTRRQDPVA WNSTFEMLSR
  1561  KVLETRYTLL PYLYTLMHKA HVEGSTVVRP LLHEFTDDRT TWDIDRQFML GPAILISPVL
  1621  ETSTFEISAY FPRARWYDYS TGTSSTSTGQ RKILKAPLDH INLHVRGGYI LPWQEPAMNT
  1681  HSSRQNFMGL IVALDDNGTA EGQVFWDDGQ SIDTYENGNY FLANFIAAQN ILQIQTIHNK
  1741  YLSDSNPLKV GYIRIWGVNT YVTQVSFTYD NRQFMETNFK SEPYNQILTI QLTDKTINLE
  1801  KLTEVTWIDG GPVLPTPTKT STIPMSSHPS PSTTNATSSE TITSSASANT TTGTTDTVPI
  1861  TTTSFPSTTS VTTNTTVPDT TSPFPTSTTN ASTNATVPIT TTPFPTSTIG VTTNATVPNT
  1921  TAPFPTNAST ASTNATVPIT TTCFATSTIG VTTNATVPDT TAPFPTNTTT ASTNATIPIT
  1981  TTPFATSTIS VTTSTTVPDT TAPFPTSTTS ASTNATPVPI TTTLFATSTI GVTTGTTVPD
  2041  TTAPFPTSTT STSTSATVPI TTTPSPTNTA DANTSNTVPN TTMPSPTSST TVSTIATVPI
  2101  SVTPSLTSTA DATISTTVLI ATTSSLTGTT DVSTSTTINN ISTPVQTNTT NASTSTNVAN
  2161  ITATSHTSTD DTVPNNTVPV TAIPSLANTG VDTTSNSFSI MTTSFSESTN AMNTTVIMAT
  2221  TSPTSTDVAS TNNDASMTNF LLATMSAGNI TSNSISITTT SFGNSVPFVT TPSPSTDATT
  2281  TSNNTNPGMT TYYQTSPTIP THTLTSIPSS ITSILSMFPT SNTFTTDKIT NFTTPTNANT
  2341  IIFNTLDTKS TMVIDATVTT TSTKDNTMSP DTTVTSIDKF TTHITQFATP HSATTTTLAL
  2401  SHTSLAPTNL SNLGTMDITD ADNSSSVTGN TTHISVSNLT TASVTITATG LDSQTPHMVI
  2461  NSVATYLPIT ATSATTDTTN ITKYALNTTT PDSTVHTSAT APTYIANAIN ATQVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 8.1 nTPM
small intestine: 5.5 nTPM
pancreas: 3.8 nTPM
duodenum: 3.2 nTPM
breast: 1.8 nTPM
colon: 1.4 nTPM

Single-cell type

tuft cells: 35 nCPM
lacrimal acinar cells: 15 nCPM
proximal tubule cells: 15 nCPM
early spermatids: 12 nCPM
late spermatids: 9.9 nCPM
salivary acinar cells: 9.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
choroid plexus: 0.2 nTPM
pons: 0.2 nTPM
thalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

OntologyGO

Biological processes

disaccharide catabolic process

Molecular functions

alpha-1,4-glucosidase activity
carbohydrate binding
glucan 1,4-alpha-glucosidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGAM2 as an antibody target. Whether an autoantibody or antibody against MGAM2 could matter depends on whether native MGAM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGAM2 is annotated at the cell surface, where native MGAM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MGAM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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