Seroatlas · Human Serome Atlas

AMY2B

Alpha-amylase 2B

Also known as: AMY2, AMY2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P19961
Gene: AMY2B
Ensembl: ENSG00000240038
Chromosome: 1
Canonical length: 511 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Cytosol
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

511 residues, UniProt reviewed canonical sequence.

>P19961|AMY2B
     1  MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP
    61  NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMSGN
   121  AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLVGL
   181  LDLALEKDYV RSKIAEYMNH LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG
   241  SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG
   301  FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP
   361  RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE HRWRQIRNMV NFRNVVDGQP
   421  FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT FSLTLQTGLP AGTYCDVISG DKINGNCTGI
   481  KIYVSDDGKA HFSISNSAED PFIAIHAESK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMY2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.2
Highest tissue expression: 33,017 nTPM

Expression across tissuesHPA

Tissue

pancreas: 33,017 nTPM
salivary gland: 257 nTPM
retina: 72 nTPM
skeletal muscle: 64 nTPM
thyroid gland: 45 nTPM
skin: 44 nTPM

Single-cell type

pancreatic acinar cells: 2,812 nCPM
myonuclei: 160 nCPM
distal convoluted tubule cells: 152 nCPM
cardiomyocytes: 60 nCPM
rod photoreceptor cells: 53 nCPM
cone photoreceptor cells: 50 nCPM

Immune cell

classical monocyte: 5.3 nTPM
intermediate monocyte: 2.7 nTPM
non-classical monocyte: 2.4 nTPM
myeloid DC: 1.7 nTPM
neutrophil: 1.3 nTPM
total PBMC: 1.3 nTPM

Brain region

cerebellum: 61 nTPM
basal ganglia: 50 nTPM
cerebral cortex: 41 nTPM
thalamus: 40 nTPM
white matter: 39 nTPM
amygdala: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: -2.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

carbohydrate metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMY2B as an antibody target. Whether an autoantibody or antibody against AMY2B could matter depends on whether native AMY2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMY2B is annotated as secreted, so native AMY2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AMY2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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