Seroatlas · Human Serome Atlas

CHID1

Chitinase domain-containing protein 1

Also known as: CHID1_HUMAN, FLJ42707, MGC3234, SI-CLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWS9
Gene: CHID1
Ensembl: ENSG00000177830
Chromosome: 11
Canonical length: 393 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Intermediate filaments
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables oligosaccharide binding activity. Involved in negative regulation of cytokine production involved in inflammatory response. Located in several cellular components, including late endosome; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q9BWS9|CHID1
     1  MRTLFNLLWL ALACSPVHTT LSKSDAKKAA SKTLLEKSQF SDKPVQDRGL VVTDLKAESV
    61  VLEHRSYCSA KARDRHFAGD VLGYVTPWNS HGYDVTKVFG SKFTQISPVW LQLKRRGREM
   121  FEVTGLHDVD QGWMRAVRKH AKGLHIVPRL LFEDWTYDDF RNVLDSEDEI EELSKTVVQV
   181  AKNQHFDGFV VEVWNQLLSQ KRVGLIHMLT HLAEALHQAR LLALLVIPPA ITPGTDQLGM
   241  FTHKEFEQLA PVLDGFSLMT YDYSTAHQPG PNAPLSWVRA CVQVLDPKSK WRSKILLGLN
   301  FYGMDYATSK DAREPVVGAR YIQTLKDHRP RMVWDSQASE HFFEYKKSRS GRHVVFYPTL
   361  KSLQVRLELA RELGVGVSIW ELGQGLDYFY DLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 141 nTPM

Expression across tissuesHPA

Tissue

pancreas: 141 nTPM
choroid plexus: 131 nTPM
epididymis: 85 nTPM
liver: 82 nTPM
salivary gland: 77 nTPM
testis: 71 nTPM

Single-cell type

late spermatids: 723 nCPM
epididymal principal cells: 255 nCPM
early primary spermatocytes: 252 nCPM
decidual stromal cells: 188 nCPM
kupffer cells: 171 nCPM
cytotrophoblasts: 152 nCPM

Immune cell

myeloid DC: 74 nTPM
plasmacytoid DC: 70 nTPM
classical monocyte: 51 nTPM
total PBMC: 46 nTPM
memory B-cell: 46 nTPM
non-classical monocyte: 46 nTPM

Brain region

choroid plexus: 84 nTPM
hypothalamus: 56 nTPM
white matter: 55 nTPM
cerebral cortex: 49 nTPM
basal ganglia: 49 nTPM
medulla oblongata: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHID1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STAB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHID1 as an antibody target. Whether an autoantibody or antibody against CHID1 could matter depends on whether native CHID1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHID1 is annotated as secreted, so native CHID1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CHID1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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