Seroatlas · Human Serome Atlas

CTBS

Di-N-acetylchitobiase

Also known as: CTB, DIAC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01459
Gene
CTBS
Ensembl
ENSG00000117151
Chromosome
1
Canonical length
385 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q01459|CTBS
     1  MSRPQLRRWR LVSSPPSGVP GLALLALLAL LALRLAAGTD CPCPEPELCR PIRHHPDFEV
    61  FVFDVGQKTW KSYDWSQITT VATFGKYDSE LMCYAHSKGA RVVLKGDVSL KDIIDPAFRA
   121  SWIAQKLNLA KTQYMDGINI DIEQEVNCLS PEYDALTALV KETTDSFHRE IEGSQVTFDV
   181  AWSPKNIDRR CYNYTGIADA CDFLFVMSYD EQSQIWSECI AAANAPYNQT LTGYNDYIKM
   241  SINPKKLVMG VPWYGYDYTC LNLSEDHVCT IAKVPFRGAP CSDAAGRQVP YKTIMKQINS
   301  SISGNLWDKD QRAPYYNYKD PAGHFHQVWY DNPQSISLKA TYIQNYRLRG IGMWNANCLD
   361  YSGDAVAKQQ TEEMWEVLKP KLLQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTBS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • liver: 3.5 nTPM
  • salivary gland: 3.2 nTPM
  • bone marrow: 3.1 nTPM
  • epididymis: 3 nTPM
  • skin: 2.3 nTPM
  • spleen: 2.3 nTPM

Single-cell type

  • neutrophils: 201 nCPM
  • retinal pigment epithelial cells: 90 nCPM
  • breast lactating cells: 69 nCPM
  • microglia: 65 nCPM
  • choroid plexus epithelial cells: 50 nCPM
  • neutrophil progenitors: 49 nCPM

Immune cell

  • neutrophil: 0.7 nTPM
  • basophil: 0.5 nTPM
  • eosinophil: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • choroid plexus: 5.7 nTPM
  • medulla oblongata: 4.4 nTPM
  • white matter: 4 nTPM
  • pons: 3.5 nTPM
  • cerebellum: 3.3 nTPM
  • midbrain: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTBS as an antibody target. Whether an autoantibody or antibody against CTBS could matter depends on whether native CTBS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTBS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTBS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTBS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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