CHIT1

Protein identityUniProt · HPA

UniProt accession

Q13231

Gene

CHIT1

Ensembl

ENSG00000133063

Chromosome

1

Canonical length

466 aa

Protein class

Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q13231|CHIT1
     1  MVRSVAWAGF MVLLMIPWGS AAKLVCYFTN WAQYRQGEAR FLPKDLDPSL CTHLIYAFAG
    61  MTNHQLSTTE WNDETLYQEF NGLKKMNPKL KTLLAIGGWN FGTQKFTDMV ATANNRQTFV
   121  NSAIRFLRKY SFDGLDLDWE YPGSQGSPAV DKERFTTLVQ DLANAFQQEA QTSGKERLLL
   181  SAAVPAGQTY VDAGYEVDKI AQNLDFVNLM AYDFHGSWEK VTGHNSPLYK RQEESGAAAS
   241  LNVDAAVQQW LQKGTPASKL ILGMPTYGRS FTLASSSDTR VGAPATGSGT PGPFTKEGGM
   301  LAYYEVCSWK GATKQRIQDQ KVPYIFRDNQ WVGFDDVESF KTKVSYLKQK GLGGAMVWAL
   361  DLDDFAGFSC NQGRYPLIQT LRQELSLPYL PSGTPELEVP KPGQPSEPEH GPSPGQDTFC
   421  QGKADGLYPN PRERSSFYSC AAGRLFQQSC PTGLVFSNSC KCCTWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHIT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

47 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0

gnomAD missense Z

-0.19

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chitin catabolic process
• immune response
• polysaccharide catabolic process
• polysaccharide digestion
• response to bacterium

Molecular functions

• chitin binding
• chitinase activity
• endochitinase activity
• hydrolase activity, hydrolyzing O-glycosyl compounds

Cellular components

• extracellular region
• extracellular space
• lysosome
• specific granule lumen
• tertiary granule lumen

Protein domainsUniProt · Pfam · InterPro

• Glycoside hydrolase family 18, catalytic domain
• Glycosyl hydrolase family 18, active site
• Chitin binding domain
• Chitinase II/V-like, catalytic domain
• Glycoside hydrolase superfamily
• Chitinase insertion domain superfamily
• Chitin binding domain superfamily
• Glycosyl hydrolase family 18
• Glycosyl hydrolases family 18
• Chitin binding Peritrophin-A domain

KeywordsUniProt

• Carbohydrate metabolism
• Chitin degradation
• Chitin-binding
• Disulfide bond
• Glycoprotein
• Glycosidase
• Hydrolase
• Lysosome
• Polysaccharide degradation
• Secreted
• Signal