Seroatlas · Human Serome Atlas

HPSE

Heparanase

Also known as: HPA, HPSE_HUMAN, HPSE1, HSE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y251
Gene
HPSE
Ensembl
ENSG00000173083
Chromosome
4
Canonical length
543 aa
Protein class
Enzymes, Metabolic proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q9Y251|HPSE
     1  MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT
    61  IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS
   121  QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS
   181  GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS
   241  QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL
   301  NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA
   361  AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM
   421  ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL
   481  RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA
   541  ACI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HPSE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 10 nTPM
  • salivary gland: 10 nTPM
  • appendix: 6.2 nTPM
  • spleen: 6.2 nTPM
  • rectum: 6 nTPM
  • colon: 5.5 nTPM

Single-cell type

  • esophageal apical cells: 315 nCPM
  • platelets: 242 nCPM
  • neutrophils: 150 nCPM
  • epicardial cells: 89 nCPM
  • kupffer cells: 64 nCPM
  • monocytes: 58 nCPM

Immune cell

  • classical monocyte: 27 nTPM
  • neutrophil: 19 nTPM
  • intermediate monocyte: 10 nTPM
  • total PBMC: 7.9 nTPM
  • T-reg: 5.2 nTPM
  • myeloid DC: 3 nTPM

Brain region

  • white matter: 8.8 nTPM
  • thalamus: 7.3 nTPM
  • medulla oblongata: 5.5 nTPM
  • hypothalamus: 5.4 nTPM
  • spinal cord: 5.4 nTPM
  • pons: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HPSE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HPSE as an antibody target. Whether an autoantibody or antibody against HPSE could matter depends on whether native HPSE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HPSE is annotated at the cell surface, where native HPSE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HPSE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HPSE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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