Seroatlas · Human Serome Atlas

HYAL4

Hyaluronidase-4

Also known as: HYAL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2M3T9
Gene
HYAL4
Ensembl
ENSG00000106302
Chromosome
7
Canonical length
481 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein which is similar in structure to hyaluronidases but lacks hyaluronidase activity. The encoded protein acts as a chondroitin-sulfate-specific endo-beta-N-acetylgalactosaminidase; that is, it exhibits hydrolytic activity toward chondroitin sulfate chains and degrades them into oligosaccharides. Proteoglycans are formed by the covalent linkage of chondroitin sulfate chains to protein. Proteoglycans are ubiquitous components of the extracellular matrix of connective tissues and are also found at the surface of many cell types where they participate in a variety of cellular processes such as cell proliferation, differentiation, migration, cell-cell recognition, extracellular matrix deposition, and tissue morphogenesis. The expression of this gene is highest in testes and placenta. [provided by RefSeq, Apr 2019]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q2M3T9|HYAL4
     1  MKVLSEGQLK LCVVQPVHLT SWLLIFFILK SISCLKPARL PIYQRKPFIA AWNAPTDQCL
    61  IKYNLRLNLK MFPVIGSPLA KARGQNVTIF YVNRLGYYPW YTSQGVPING GLPQNISLQV
   121  HLEKADQDIN YYIPAEDFSG LAVIDWEYWR PQWARNWNSK DVYRQKSRKL ISDMGKNVSA
   181  TDIEYLAKVT FEESAKAFMK ETIKLGIKSR PKGLWGYYLY PDCHNYNVYA PNYSGSCPED
   241  EVLRNNELSW LWNSSAALYP SIGVWKSLGD SENILRFSKF RVHESMRIST MTSHDYALPV
   301  FVYTRLGYRD EPLFFLSKQD LVSTIGESAA LGAAGIVIWG DMNLTASKAN CTKVKQFVSS
   361  DLGSYIANVT RAAEVCSLHL CRNNGRCIRK MWNAPSYLHL NPASYHIEAS EDGEFTVKGK
   421  ASDTDLAVMA DTFSCHCYQG YEGADCREIK TADGCSGVSP SPGSLMTLCL LLLASYRSIQ
   481  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HYAL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
3.8 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 3.8 nTPM
  • placenta: 3.7 nTPM
  • testis: 1.9 nTPM
  • retina: 0.9 nTPM
  • skin: 0.9 nTPM
  • tonsil: 0.9 nTPM

Single-cell type

  • myonuclei: 98 nCPM
  • renal collecting duct intercalated cells: 49 nCPM
  • epididymal clear cells: 43 nCPM
  • extravillous trophoblasts: 34 nCPM
  • cytotrophoblasts: 19 nCPM
  • migrating cytotrophoblasts: 16 nCPM

Immune cell

  • neutrophil: 0.6 nTPM
  • naive B-cell: 0.2 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • white matter: 6.5 nTPM
  • cerebellum: 6 nTPM
  • cerebral cortex: 5.9 nTPM
  • pons: 5.6 nTPM
  • amygdala: 5.4 nTPM
  • basal ganglia: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HYAL4 as an antibody target. Whether an autoantibody or antibody against HYAL4 could matter depends on whether native HYAL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HYAL4 is annotated at the cell surface, where native HYAL4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HYAL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HYAL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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