AMY1B
Alpha-amylase 1B
Also known as: AMY1, AMY1B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DTE7
- Gene
- AMY1B
- Ensembl
- ENSG00000174876
- Chromosome
- 1
- Canonical length
- 511 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted secreted proteins
- Subcellular location
- Golgi apparatus,Cytosol
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
511 residues, UniProt reviewed canonical sequence.
>P0DTE7|AMY1B
1 MKLFWLLFTI GFCWAQYSSN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP
61 NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN
121 AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLSGL
181 LDLALGKDYV RSKIAEYMNH LIDIGVAGFR IDASKHMWPG DIKAILDKLH NLNSNWFPEG
241 SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG
301 FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP
361 RYFENGKDVN DWVGPPNDNG VTKEVTINPD TTCGNDWVCE HRWRQIRNMV NFRNVVDGQP
421 FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT FSLTLQTGLP AGTYCDVISG DKINGNCTGI
481 KIYVSDDGKA HFSISNSAED PFIAIHAESK LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against AMY1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.2
- Highest tissue expression
- 9,825 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 9,825 nTPM
- cervix: 102 nTPM
- pancreas: 28 nTPM
- fallopian tube: 27 nTPM
- lung: 3.6 nTPM
- tonsil: 2.6 nTPM
Single-cell type
- salivary acinar cells: 5.4 nCPM
- pancreatic acinar cells: 1.7 nCPM
- salivary myoepithelial cells: 1.3 nCPM
- neutrophils: 0.4 nCPM
- early spermatids: 0.1 nCPM
- fallopian tube ciliated cells: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.09
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads AMY1B as an antibody target. Whether an autoantibody or antibody against AMY1B could matter depends on whether native AMY1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
AMY1B is annotated as secreted, so native AMY1B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label AMY1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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