HEXD
Hexosaminidase D
Also known as: FLJ23825, HEXD_HUMAN, HEXDC
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WVB3
- Gene
- HEXD
- Ensembl
- ENSG00000169660
- Chromosome
- 17
- Canonical length
- 486 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoli fibrillar center,Mitochondria
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables beta-N-acetylhexosaminidase activity. Predicted to be involved in carbohydrate metabolic process. Located in extracellular vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
486 residues, UniProt reviewed canonical sequence.
>Q8WVB3|HEXD
1 MSGSTPFQMR LVHLDLKGAP PKVSYLSEIF PLFRALGANG LLIEYEDMFP YEGPLRLLRA
61 KYAYSPSEIK EILHLAGLNE LEVIPLVQTF GHMEFVLKHT AFAHLREVGS FPCTLNPHEA
121 ESLALVGAMI DQVLELHPGA QRLHIGCDEV YYLGEGEASR RWLQQEQNST GKLCLSHMRA
181 VASGVKARRP SVTPLVWDDM LRDLPEDQLA ASGVPQLVEP VLWDYTADLD VHGKVLLMQK
241 YRRCGFPQLW AASAFKGATG PSQAVPPVEH HLRNHVQWLQ VAGSGPTDSL QGIILTGWQR
301 YDHYSVLCEL LPAGVPSLAA CLQLLLRGGF DEDVKAKVEN LLGISSLEKT DPVREGAGSF
361 PGSNILALVT QVSLHLRSSV DALLEGNRYV TGWFSPYHRQ RKLIHPVMVQ HIQPAALSLL
421 AQWSTLVQEL EAALQLAFYP DAVEEWLEEN VHPSLQRLQA LLQDLSEVSA PPLPPTSPGR
481 DVAQDPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HEXD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 41 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 41 nTPM
- skeletal muscle: 22 nTPM
- adipose tissue: 20 nTPM
- blood vessel: 17 nTPM
- spleen: 15 nTPM
- liver: 15 nTPM
Single-cell type
- pancreatic acinar cells: 67 nCPM
- proximal tubule cells: 64 nCPM
- thyrotrophs: 64 nCPM
- renal collecting duct intercalated cells: 63 nCPM
- gonadotrophs: 56 nCPM
- leydig cells: 56 nCPM
Immune cell
- basophil: 9.1 nTPM
- intermediate monocyte: 6.6 nTPM
- eosinophil: 5 nTPM
- neutrophil: 4.7 nTPM
- naive B-cell: 3.7 nTPM
- myeloid DC: 3.2 nTPM
Brain region
- cerebellum: 19 nTPM
- choroid plexus: 18 nTPM
- white matter: 18 nTPM
- pons: 15 nTPM
- thalamus: 15 nTPM
- medulla oblongata: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.14
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HEXD as an antibody target. Whether an autoantibody or antibody against HEXD could matter depends on whether native HEXD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HEXD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HEXD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...