CHIA

Protein identityUniProt · HPA

UniProt accession

Q9BZP6

Gene

CHIA

Ensembl

ENSG00000134216

Chromosome

1

Canonical length

476 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Secretome location

Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q9BZP6|CHIA
     1  MTKLILLTGL VLILNLQLGS AYQLTCYFTN WAQYRPGLGR FMPDNIDPCL CTHLIYAFAG
    61  RQNNEITTIE WNDVTLYQAF NGLKNKNSQL KTLLAIGGWN FGTAPFTAMV STPENRQTFI
   121  TSVIKFLRQY EFDGLDFDWE YPGSRGSPPQ DKHLFTVLVQ EMREAFEQEA KQINKPRLMV
   181  TAAVAAGISN IQSGYEIPQL SQYLDYIHVM TYDLHGSWEG YTGENSPLYK YPTDTGSNAY
   241  LNVDYVMNYW KDNGAPAEKL IVGFPTYGHN FILSNPSNTG IGAPTSGAGP AGPYAKESGI
   301  WAYYEICTFL KNGATQGWDA PQEVPYAYQG NVWVGYDNIK SFDIKAQWLK HNKFGGAMVW
   361  AIDLDDFTGT FCNQGKFPLI STLKKALGLQ SASCTAPAQP IEPITAAPSG SGNGSGSSSS
   421  GGSSGGSGFC AVRANGLYPV ANNRNAFWHC VNGVTYQQNC QAGLVFDTSC DCCNWA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHIA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

340 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.24

gnomAD pLI

0

gnomAD missense Z

-0.45

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• chitin catabolic process
• immune system process
• polysaccharide catabolic process
• polysaccharide digestion
• positive regulation of chemokine production
• production of molecular mediator involved in inflammatory response
• chitin metabolic process

Molecular functions

• chitin binding
• chitinase activity
• endochitinase activity
• kinase binding

Cellular components

• cytoplasm
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Glycoside hydrolase family 18, catalytic domain
• Glycosyl hydrolase family 18, active site
• Chitin binding domain
• Chitinase II/V-like, catalytic domain
• Glycoside hydrolase superfamily
• Chitinase insertion domain superfamily
• Chitin binding domain superfamily
• Glycosyl hydrolase family 18
• Glycosyl hydrolases family 18
• Chitin binding Peritrophin-A domain

KeywordsUniProt

• Apoptosis
• Carbohydrate metabolism
• Chitin degradation
• Chitin-binding
• Cytoplasm
• Disulfide bond
• Glycosidase
• Hydrolase
• Immunity
• Inflammatory response
• Polysaccharide degradation
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of CHIA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EGFR