Seroatlas · Human Serome Atlas

OVGP1

Oviduct-specific glycoprotein

Also known as: CHIT5, MUC9, OVGP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12889
Gene
OVGP1
Ensembl
ENSG00000085465
Chromosome
1
Canonical length
678 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Vesicles,Microtubules
Secretome location
Secreted in female reproductive system

OverviewNCBI Gene

This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>Q12889|OVGP1
     1  MWKLLLWVGL VLVLKHHDGA AHKLVCYFTN WAHSRPGPAS ILPHDLDPFL CTHLIFAFAS
    61  MNNNQIVAKD LQDEKILYPE FNKLKERNRE LKTLLSIGGW NFGTSRFTTM LSTFANREKF
   121  IASVISLLRT HDFDGLDLFF LYPGLRGSPM HDRWTFLFLI EELLFAFRKE ALLTMRPRLL
   181  LSAAVSGVPH IVQTSYDVRF LGRLLDFINV LSYDLHGSWE RFTGHNSPLF SLPEDPKSSA
   241  YAMNYWRKLG APSEKLIMGI PTYGRTFRLL KASKNGLQAR AIGPASPGKY TKQEGFLAYF
   301  EICSFVWGAK KHWIDYQYVP YANKGKEWVG YDNAISFSYK AWFIRREHFG GAMVWTLDMD
   361  DVRGTFCGTG PFPLVYVLND ILVRAEFSST SLPQFWLSSA VNSSSTDPER LAVTTAWTTD
   421  SKILPPGGEA GVTEIHGKCE NMTITPRGTT VTPTKETVSL GKHTVALGEK TEITGAMTMT
   481  SVGHQSMTPG EKALTPVGHQ SVTTGQKTLT SVGYQSVTPG EKTLTPVGHQ SVTPVSHQSV
   541  SPGGTTMTPV HFQTETLRQN TVAPRRKAVA REKVTVPSRN ISVTPEGQTM PLRGENLTSE
   601  VGTHPRMGNL GLQMEAENRM MLSSSPVIQL PEQTPLAFDN RFVPIYGNHS SVNSVTPQTS
   661  PLSLKKEIPE NSAVDEEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OVGP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
1,951 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 1,951 nTPM
  • endometrium: 14 nTPM
  • cerebellum: 11 nTPM
  • testis: 9.1 nTPM
  • liver: 7.9 nTPM
  • ovary: 7.5 nTPM

Single-cell type

  • fallopian secretory cells: 3,283 nCPM
  • fallopian tube ciliated cells: 133 nCPM
  • syncytiotrophoblasts: 28 nCPM
  • endometrial luminal cells: 11 nCPM
  • brain inhibitory neurons: 11 nCPM
  • brain excitatory neurons: 9.5 nCPM

Immune cell

  • naive CD4 T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • white matter: 7.3 nTPM
  • cerebellum: 6.8 nTPM
  • hippocampal formation: 6.2 nTPM
  • basal ganglia: 6.1 nTPM
  • pons: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OVGP1 as an antibody target. Whether an autoantibody or antibody against OVGP1 could matter depends on whether native OVGP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OVGP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OVGP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OVGP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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