Seroatlas · Human Serome Atlas

LCTL

Lactase-like protein

Also known as: FLJ33279, KLG, KLPH, LCTL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWM7
Gene
LCTL
Ensembl
ENSG00000188501
Chromosome
15
Canonical length
567 aa
Protein class
Cancer-related genes, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q6UWM7|LCTL
     1  MKPVWVATLL WMLLLVPRLG AARKGSPEEA SFYYGTFPLG FSWGVGSSAY QTEGAWDQDG
    61  KGPSIWDVFT HSGKGKVLGN ETADVACDGY YKVQEDIILL RELHVNHYRF SLSWPRLLPT
   121  GIRAEQVNKK GIEFYSDLID ALLSSNITPI VTLHHWDLPQ LLQVKYGGWQ NVSMANYFRD
   181  YANLCFEAFG DRVKHWITFS DPRAMAEKGY ETGHHAPGLK LRGTGLYKAA HHIIKAHAKA
   241  WHSYNTTWRS KQQGLVGISL NCDWGEPVDI SNPKDLEAAE RYLQFCLGWF ANPIYAGDYP
   301  QVMKDYIGRK SAEQGLEMSR LPVFSLQEKS YIKGTSDFLG LGHFTTRYIT ERNYPSRQGP
   361  SYQNDRDLIE LVDPNWPDLG SKWLYSVPWG FRRLLNFAQT QYGDPPIYVM ENGASQKFHC
   421  TQLCDEWRIQ YLKGYINEML KAIKDGANIK GYTSWSLLDK FEWEKGYSDR YGFYYVEFND
   481  RNKPRYPKAS VQYYKKIIIA NGFPNPREVE SWYLKALETC SINNQMLAAE PLLSHMQMVT
   541  EIVVPTVCSL CVLITAVLLM LLLRRQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCTL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 2.5 nTPM
  • basal ganglia: 0.8 nTPM
  • midbrain: 0.8 nTPM
  • amygdala: 0.7 nTPM
  • skeletal muscle: 0.6 nTPM
  • cerebral cortex: 0.5 nTPM

Single-cell type

  • late spermatids: 16 nCPM
  • early spermatids: 8.4 nCPM
  • astrocytes: 4 nCPM
  • undifferentiated spermatogonia: 2.9 nCPM
  • ependymal cells: 2.8 nCPM
  • differentiating spermatogonia: 2.7 nCPM

Immune cell

  • neutrophil: 0.6 nTPM
  • basophil: 0.4 nTPM
  • NK-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • white matter: 6.6 nTPM
  • medulla oblongata: 4.8 nTPM
  • spinal cord: 3.3 nTPM
  • thalamus: 3.3 nTPM
  • basal ganglia: 3.1 nTPM
  • pons: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
0.88
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCTL as an antibody target. Whether an autoantibody or antibody against LCTL could matter depends on whether native LCTL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCTL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCTL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCTL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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