Acyl-CoA N-acyltransferase
IPR016181
Definition
This entry represents a structural domain found in several acyl-CoA acyltransferase enzymes. This domain has a 3-layer α/β/α structure that contains mixed β-sheets, and can be found in the following proteins: N-acetyl transferase (NAT) family members, including aminoglycoside N-acetyltransferases PMID:12592013, the histone acetyltransferase domain of P300/CBP associating factor PCAF PMID:10393169, the catalytic domain of GCN5 histone acetyltransferase PMID:10430873, and diamine acetyltransferase 1 PMID:16455797. Autoinducer synthetases, such as protein LasI PMID:15306017 and acyl-homoserinelactone synthase EsaI PMID:11931774. Leucyl/phenylalanyl-tRNA-protein transferase (LFTR), a close relative of the non-ribosomal peptidyltransferases; there is a deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events PMID:17242373. Ornithine decarboxylase antizyme, which may have evolved a different function for this domain, although the putative active site maps to the same location in the common fold. Arginine N-succinyltransferase, alpha chain, AstA, which contains an extra C-terminal domain that is similar to the double-psi β-barrel fold domain (missing one strand and untangled ψ-loops). Several proteins carry a duplication of this domain, which consists of two NAT-like domains swapped with the C-terminal strands, including: N-myristoyl transferase (NMT) PMID:11371195. FemXAB non ribosomal peptidyl transferases, including methicillin-resistance protein FemA (transfer glycyl residue from tRNA-Gly) PMID:12176388 and peptidyl transferase FemX PMID:14962386. Hypothetical protein cg14615-pa from Drosophila melanogaster (Fruit fly).
44 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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