Seroatlas · Human Serome Atlas

ELP3

Elongator complex protein 3

Also known as: ELP3_HUMAN, FLJ10422, KAT9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9T3
Gene: ELP3
Ensembl: ENSG00000134014
Chromosome: 8
Canonical length: 547 aa
Protein class: Disease related genes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables acetyltransferase activity and phosphorylase kinase regulator activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytosol and nucleolus. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q9H9T3|ELP3
     1  MRQKRKGDLS PAELMMLTIG DVIKQLIEAH EQGKDIDLNK VKTKTAAKYG LSAQPRLVDI
    61  IAAVPPQYRK VLMPKLKAKP IRTASGIAVV AVMCKPHRCP HISFTGNICV YCPGGPDSDF
   121  EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH RIEQLKQLGH SVDKVEFIVM GGTFMALPEE
   181  YRDYFIRNLH DALSGHTSNN IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC
   241  TRLEIGVQSV YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ
   301  FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLVELVA RILALVPPWT
   361  RVYRVQRDIP MPLVSSGVEH GNLRELALAR MKDLGIQCRD VRTREVGIQE IHHKVRPYQV
   421  ELVRRDYVAN GGWETFLSYE DPDQDILIGL LRLRKCSEET FRFELGGGVS IVRELHVYGS
   481  VVPVSSRDPT KFQHQGFGML LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP
   541  YMVKMLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 27 nTPM
tongue: 25 nTPM
cervix: 24 nTPM
endometrium: 21 nTPM
liver: 20 nTPM
cerebral cortex: 19 nTPM

Single-cell type

renal collecting duct intercalated cells: 299 nCPM
endometrial luminal cells: 231 nCPM
endometrial glandular cells: 164 nCPM
cone photoreceptor cells: 135 nCPM
endometrial ciliated cells: 114 nCPM
sertoli cells: 83 nCPM

Immune cell

MAIT T-cell: 29 nTPM
non-classical monocyte: 27 nTPM
memory CD8 T-cell: 26 nTPM
gdT-cell: 25 nTPM
NK-cell: 25 nTPM
T-reg: 23 nTPM

Brain region

hypothalamus: 34 nTPM
cerebral cortex: 32 nTPM
basal ganglia: 32 nTPM
white matter: 32 nTPM
cerebellum: 31 nTPM
pons: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ELP3.

Disease | AllUniProt

Conditions ELP3 is implicated in, by any mechanism.

Amyotrophic lateral sclerosis (ALS) MIM:105400

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 1.83
DepMap mean gene effect: -0.84
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

4 iron, 4 sulfur cluster binding
acetyltransferase activity
metal ion binding
tRNA binding
tRNA uridine(34) acetyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

GNAT domain
Elp3/MiaA/NifB-like, radical SAM core domain
Radical SAM
Acyl-CoA N-acyltransferase
Radical SAM superfamily
Radical SAM superfamily
Radical SAM, C-terminal extension
Elongator complex protein 3-like
ELP3/YhcC
ELP3-like, N-terminal domain
Radical_SAM C-terminal domain
ELP3 N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELP3 as an antibody target. Whether an autoantibody or antibody against ELP3 could matter depends on whether native ELP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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