NAT14
Probable N-acetyltransferase 14
Also known as: KLP1, NAT14_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WUY8
- Gene
- NAT14
- Ensembl
- ENSG00000090971
- Chromosome
- 19
- Canonical length
- 206 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Predicted to enable N-acetyltransferase activity. Predicted to be involved in DNA-templated transcription initiation and positive regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
206 residues, UniProt reviewed canonical sequence.
>Q8WUY8|NAT14
1 MAPSHLSVRE MREDEKPLVL EMLKAGVKDT ENRVALHALT RPPALLLLAA ASSGLRFVLA
61 SFALALLLPV FLAVAAVKLG LRARWGSLPP PGGLGGPWVA VRGSGDVCGV LALAPGTNAG
121 DGARVTRLSV SRWHRRRGVG RRLLAFAEAR ARAWAGGMGE PRARLVVPVA VAAWGVGGML
181 EGCGYQAEGG WGCLGYTLVR EFSKDLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NAT14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 66 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 66 nTPM
- cerebral cortex: 53 nTPM
- basal ganglia: 50 nTPM
- thymus: 50 nTPM
- pituitary gland: 50 nTPM
- hypothalamus: 45 nTPM
Single-cell type
- fallopian tube ciliated cells: 91 nCPM
- respiratory ciliated cells: 78 nCPM
- retinal horizontal cells: 72 nCPM
- epididymal efferent duct ciliated cells: 69 nCPM
- retinal amacrine cells: 55 nCPM
- ependymal cells: 50 nCPM
Immune cell
- neutrophil: 0.4 nTPM
- plasmacytoid DC: 0.4 nTPM
- naive B-cell: 0.3 nTPM
- MAIT T-cell: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- memory B-cell: 0.1 nTPM
Brain region
- thalamus: 49 nTPM
- cerebral cortex: 42 nTPM
- midbrain: 42 nTPM
- amygdala: 41 nTPM
- hypothalamus: 40 nTPM
- basal ganglia: 39 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.66
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NAT14 as an antibody target. Whether an autoantibody or antibody against NAT14 could matter depends on whether native NAT14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NAT14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NAT14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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