ATE1

Protein identityUniProt · HPA

UniProt accession

O95260

Gene

ATE1

Ensembl

ENSG00000107669

Chromosome

10

Canonical length

518 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>O95260|ATE1
     1  MAFWAGGSPS VVDYFPSEDF YRCGYCKNES GSRSNGMWAH SMTVQDYQDL IDRGWRRSGK
    61  YVYKPVMNQT CCPQYTIRCR PLQFQPSKSH KKVLKKMLKF LAKGEVPKGS CEDEPMDSTM
   121  DDAVAGDFAL INKLDIQCDL KTLSDDIKES LESEGKNSKK EEPQELLQSQ DFVGEKLGSG
   181  EPSHSVKVHT VPKPGKGADL SKPPCRKAKE IRKERKRLKL MQQNPAGELE GFQAQGHPPS
   241  LFPPKAKSNQ PKSLEDLIFE SLPENASHKL EVRVVRSSPP SSQFKATLLE SYQVYKRYQM
   301  VIHKNPPDTP TESQFTRFLC SSPLEAETPP NGPDCGYGSF HQQYWLDGKI IAVGVIDILP
   361  NCVSSVYLYY DPDYSFLSLG VYSALREIAF TRQLHEKTSQ LSYYYMGFYI HSCPKMKYKG
   421  QYRPSDLLCP ETYVWVPIEQ CLPSLENSKY CRFNQDPEAV DEDRSTEPDR LQVFHKRAIM
   481  PYGVYKKQQK DPSEEAAVLQ YASLVGQKCS ERMLLFRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0.04

gnomAD missense Z

0.63

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• proteasomal protein catabolic process
• protein arginylation
• response to oxidative stress
• ubiquitin-dependent protein catabolic process
• ubiquitin-dependent protein catabolic process via the N-end rule pathway

Molecular functions

• arginyl-tRNA--protein transferase activity

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Acyl-CoA N-acyltransferase
• N-end aminoacyl transferase, N-terminal
• N-end rule aminoacyl transferase, C-terminal
• Arginine-tRNA-protein transferase 1, eukaryotic
• N-end rule aminoacyl transferase
• Arginine-tRNA-protein transferase, N terminus
• Arginine-tRNA-protein transferase, C terminus

KeywordsUniProt

• Acyltransferase
• Cytoplasm
• Nucleus
• Phosphoprotein
• Transferase
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of ATE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LIAT1
• SUV39H1