Seroatlas · Human Serome Atlas

SAT1

Diamine acetyltransferase 1

Also known as: SAT, SAT1_HUMAN, SSAT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P21673
Gene
SAT1
Ensembl
ENSG00000130066
Chromosome
X
Canonical length
171 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

171 residues, UniProt reviewed canonical sequence.

>P21673|SAT1
     1  MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP FYHCLVAEVP
    61  KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY RGFGIGSEIL KNLSQVAMRC
   121  RCSSMHFLVA EWNEPSINFY KRRGASDLSS EEGWRLFKID KEYLLKMATE E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
971 nTPM

Expression across tissuesHPA

Tissue

  • lung: 971 nTPM
  • choroid plexus: 954 nTPM
  • bone marrow: 834 nTPM
  • liver: 735 nTPM
  • adipose tissue: 612 nTPM
  • salivary gland: 576 nTPM

Single-cell type

  • epididymal basal cells: 11,105 nCPM
  • neutrophils: 8,490 nCPM
  • kupffer cells: 6,462 nCPM
  • endometrial luminal cells: 5,738 nCPM
  • endometrial glandular cells: 5,636 nCPM
  • cdc: 5,324 nCPM

Immune cell

  • non-classical monocyte: 2,462 nTPM
  • intermediate monocyte: 1,846 nTPM
  • neutrophil: 1,585 nTPM
  • total PBMC: 746 nTPM
  • classical monocyte: 654 nTPM
  • basophil: 402 nTPM

Brain region

  • cerebral cortex: 136 nTPM
  • choroid plexus: 95 nTPM
  • hypothalamus: 86 nTPM
  • white matter: 83 nTPM
  • thalamus: 73 nTPM
  • medulla oblongata: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.87
gnomAD missense Z
1.71
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAT1 as an antibody target. Whether an autoantibody or antibody against SAT1 could matter depends on whether native SAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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